[HTML][HTML] Metformin improves ovarian cancer sensitivity to paclitaxel and platinum-based drugs: a review of in vitro findings

G Tossetta - International Journal of Molecular Sciences, 2022 - mdpi.com
Ovarian cancer is one of the most dangerous gynecologic cancers worldwide, showing a
high fatality rate and recurrence due to diagnosis at an advanced stage of the disease and …

Plumbing mysterious RNAs in “dark genome” for the conquest of human diseases

LA Huang, C Lin, L Yang - Molecular Therapy, 2023 - cell.com
Next-generation sequencing has revealed that less than 2% of transcribed genes are
translated into proteins, with a large portion transcribed into noncoding RNAs (ncRNAs) …

[HTML][HTML] Long noncoding RNAs in the pathogenesis of insulin resistance

W Yang, Y Lyu, R Xiang, J Yang - International journal of molecular …, 2022 - mdpi.com
Insulin resistance (IR), designated as the blunted response of insulin target tissues to
physiological level of insulin, plays crucial roles in the development and progression of …

[HTML][HTML] Posttranscriptional regulation of the plasminogen activation system by non-coding RNA in cancer

M Alfieri, L Meo, P Ragno - International Journal of Molecular Sciences, 2023 - mdpi.com
Various species of non-coding RNAs (ncRNAs) may act as functional molecules regulating
diverse biological processes. In cancer cell biology, ncRNAs include RNAs that regulate the …

BioDeepfuse: a hybrid deep learning approach with integrated feature extraction techniques for enhanced non-coding RNA classification

AP Avila Santos, BLS de Almeida, RP Bonidia… - RNA biology, 2024 - Taylor & Francis
The accurate classification of non-coding RNA (ncRNA) sequences is pivotal for advanced
non-coding genome annotation and analysis, a fundamental aspect of genomics that …

Functions, mechanisms, and clinical applications of lncRNA LINC00857 in cancer pathogenesis

H Aldayyeni, A Hjazi, S Shahab, J Gupta, HO Alsaab… - Human Cell, 2023 - Springer
Emerging data indicated that long noncoding RNAs (lncRNAs) are crucial players in the
biological processes via regulating epigenetics, transcription, and protein translation. A …

Long non‑coding RNAs in gallbladder cancer: From mechanisms to therapeutic opportunities

Y He, X Du, F Yuan, C Yan… - International …, 2024 - spandidos-publications.com
Due to the lack of specific symptoms, characteristic diagnostic markers and effective
comprehensive treatment, gallbladder cancer (GBC) is currently considered one of the most …

DeepdlncUD: Predicting regulation types of small molecule inhibitors on modulating lncRNA expression by deep learning

J Sun, S Si, J Ru, X Wang - Computers in Biology and Medicine, 2023 - Elsevier
Targeting lncRNAs by small molecules (SM-lncR) to alter their expression levels has
emerged as an important therapeutic modality for disease treatment. To date, no …

[HTML][HTML] Detecting the FLJ22447 lncRNA in Ovarian Cancer with Cyclopentane-Modified FIT-PNAs (cpFIT-PNAs)

ST Mannully, R Mahajna, H Nazzal, S Maree, H Zheng… - Biomolecules, 2024 - mdpi.com
Ovarian cancer (OC) is one of the most lethal gynecologic cancers that is typically
diagnosed at the very late stage of disease progression. Thus, there is an unmet need to …

A new tandem repeat‐enriched lncRNA XLOC_008672 promotes gastric carcinogenesis by regulating G3BP1 expression

L Li, S Yu, N Dou, X Wang, Y Gao, Y Li - Cancer Science, 2024 - Wiley Online Library
Aberrant expression of forkhead box transcription factor 1 (FOXM1) plays critical roles in a
variety of human malignancies and predicts poor prognosis. However, little is known about …