[HTML][HTML] Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities
Q Pei, Q Yi, L Tang - International Journal of Molecular Sciences, 2023 - mdpi.com
The liver is a critical system for metabolism in human beings, which plays an essential role
in an abundance of physiological processes and is vulnerable to endogenous or exogenous …
in an abundance of physiological processes and is vulnerable to endogenous or exogenous …
Natural essential oils efficacious in internal organs fibrosis treatment: Mechanisms of action and application perspectives
S Yu, Y Long, D Li, A Shi, J Deng, Y Ma, J Wen… - Pharmacological …, 2022 - Elsevier
Internal organs fibrosis (IOF) is the leading cause of morbidity and mortality in most chronic
inflammatory diseases, which is responsible for 45% of deaths due to disease. However …
inflammatory diseases, which is responsible for 45% of deaths due to disease. However …
[HTML][HTML] Costunolide alleviated DDC induced ductular reaction and inflammatory response in murine model of cholestatic liver disease
J Hao, X Shen, K Lu, Y Xu, Y Chen, J Liu… - Journal of Traditional …, 2023 - Elsevier
Purpose Cholestatic liver diseases are groups of hepatobiliary diseases without curative
drug-based therapy options. Regulation of bile acid (BA) metabolism, hepatoperiductal …
drug-based therapy options. Regulation of bile acid (BA) metabolism, hepatoperiductal …
[HTML][HTML] Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo
H Huang, S Park, H Zhang, S Park, W Kwon… - Journal of Experimental …, 2021 - Springer
Background Colorectal cancer (CRC) is a clinically challenging malignant tumor worldwide.
As a natural product and sesquiterpene lactone, Costunolide (CTD) has been reported to …
As a natural product and sesquiterpene lactone, Costunolide (CTD) has been reported to …
Aucklandiae Radix and Vladimiriae Radix: A systematic review in ethnopharmacology, phytochemistry and pharmacology
Z Huang, C Wei, K Yang, Z Yu, Z Wang, H Hu - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Aucklandiae Radix (AR) and Vladimiriae Radix
(VR), as commonly used traditional Chinese herbal medicine, were widely used in the …
(VR), as commonly used traditional Chinese herbal medicine, were widely used in the …
[HTML][HTML] Novel therapeutic targets in liver fibrosis
J Zhang, Q Liu, J He, Y Li - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Liver fibrosis is end-stage liver disease that can be rescued. If irritation continues due to viral
infection, schistosomiasis and alcoholism, liver fibrosis can progress to liver cirrhosis and …
infection, schistosomiasis and alcoholism, liver fibrosis can progress to liver cirrhosis and …
Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor …
FC Meng, W Zong, XD Wei, YY Tao, GW Wang… - Phytomedicine, 2021 - Elsevier
Background Cholestasis is characterized by accumulation of bile components in liver and
systemic circulation. Restoration of bile acid homeostasis via activating farnesoid x receptor …
systemic circulation. Restoration of bile acid homeostasis via activating farnesoid x receptor …
[HTML][HTML] Therapeutic effect of Costunolide in Autoimmune Hepatitis: Network Pharmacology and experimental validation
Z Huang, S Nie, S Wang, H Wang, J Gong, W Yan… - Pharmaceuticals, 2023 - mdpi.com
Novel treatments for autoimmune hepatitis (AIH) are highly demanded due to the limitations
of existing therapeutic agents. Costunolide is a promising candidate due to its anti …
of existing therapeutic agents. Costunolide is a promising candidate due to its anti …
[HTML][HTML] Costunolide induces apoptosis via the reactive oxygen species and protein kinase B pathway in Oral cancer cells
H Huang, JK Yi, SG Lim, S Park, H Zhang… - International Journal of …, 2021 - mdpi.com
Oral cancer (OC) has been attracted research attention in recent years as result of its high
morbidity and mortality. Costunolide (CTD) possesses potential anticancer and bioactive …
morbidity and mortality. Costunolide (CTD) possesses potential anticancer and bioactive …
[HTML][HTML] The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis
M Ghashghaeinia, P Koralkova, D Giustarini… - Apoptosis, 2020 - Springer
Costunolide, a natural sesquiterpene lactone, has multiple pharmacological activities such
as neuroprotection or induction of apoptosis and eryptosis. However, the effects of …
as neuroprotection or induction of apoptosis and eryptosis. However, the effects of …