Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging

JE Slemmer, JJ Shacka, MI Sweeney… - Current medicinal …, 2008 - ingentaconnect.com
The overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS)
is a common underlying mechanism of many neuropathologies, as they have been shown to …

Pathophysiology of traumatic brain injury

MJ McGinn, JT Povlishock - Neurosurgery Clinics, 2016 - neurosurgery.theclinics.com
Traumatic brain injury (TBI) remains one of the most complex diseases known in the most
complex of all organs in the body. The causes of TBI are many and varied and include …

The pathophysiology of concussion

MC Choe - Current pain and headache reports, 2016 - Springer
Concussion is a significant issue in medicine and the media today. With growing interest on
the long-term effects of sports participation, it is important to understand what occurs in the …

Chronic cerebrovascular dysfunction after traumatic brain injury

A Jullienne, A Obenaus, A Ichkova… - Journal of …, 2016 - Wiley Online Library
Traumatic brain injuries (TBI) often involve vascular dysfunction that leads to long‐term
alterations in physiological and cognitive functions of the brain. Indeed, all the cells that form …

Gamma oscillations in the hippocampus require high complex I gene expression and strong functional performance of mitochondria

O Kann, C Huchzermeyer, R Kovacs, S Wirtz… - Brain, 2011 - academic.oup.com
Fast neuronal network oscillations in the gamma range (∼ 30–90 Hz) have been implicated
in complex brain functions such as sensory processing, memory formation and, perhaps …

Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats

S Wang, W Lv, H Zhang, Y Liu, L Li, JR Jefferson… - Geroscience, 2020 - Springer
Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the
underlying mechanisms are not well understood. The present study, utilizing a non-obese …

An analysis of regional microvascular loss and recovery following two grades of fluid percussion trauma: a role for hypoxia-inducible factors in traumatic brain injury

E Park, JD Bell, IP Siddiq… - Journal of Cerebral Blood …, 2009 - journals.sagepub.com
Secondary hypoxic/ischemic injuries, stemming from reductions in cerebral blood flow are
important contributing factors in progressive neuronal dysfunction after brain trauma. A …

Neuroprotection by acetyl-L-carnitine after traumatic injury to the immature rat brain

S Scafidi, J Racz, J Hazelton, MC McKenna… - Developmental …, 2011 - karger.com
Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in children and is
characterized by reduced aerobic cerebral energy metabolism early after injury, possibly …

Mitochondrial function and energy metabolism in cancer cells: past overview and future perspectives

A Mayevsky - Mitochondrion, 2009 - Elsevier
The involvements of energy metabolism aspects of mitochondrial dysfunction in cancer
development, proliferation and possible therapy, have been investigated since Otto Warburg …

[HTML][HTML] Mitochondrial dysfunction underlies impaired neurovascular coupling following traumatic brain injury

G Van Hameren, J Muradov, A Minarik… - Neurobiology of …, 2023 - Elsevier
Traumatic brain injury (TBI) involves an acute injury (primary damage), which may evolve in
the hours to days after impact (secondary damage). Seizures and cortical spreading …