A review of Glycogen Synthase Kinase-3 (GSK3) inhibitors for cancers therapies

R Thapa, G Gupta, AA Bhat, WH Almalki… - International journal of …, 2023 - Elsevier
The intricate molecular pathways governing cancer development and progression have
spurred intensive investigations into novel therapeutic targets. Glycogen Synthase Kinase-3 …

[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin

L Qin, N Liu, C Bao, D Yang, G Ma, W Yi… - Acta Pharmacologica …, 2023 - nature.com
Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …

Cancer metastasis as a non-healing wound

M Deyell, CS Garris, AM Laughney - British journal of cancer, 2021 - nature.com
Most cancer deaths are caused by metastasis: recurrence of disease by disseminated
tumour cells at sites distant from the primary tumour. Large numbers of disseminated tumour …

Inflammation, fibrosis and cancer: mechanisms, therapeutic options and challenges

B Wu, QH Sodji, AK Oyelere - Cancers, 2022 - mdpi.com
Simple Summary Inflammation is like the proverbial double-edged sword. Controlled short-
term inflammation could be a protective response while uncontrolled inflammation sustains …

Anticancer and anti-inflammatory properties of mangiferin: A review of its molecular mechanisms

S Mei, H Ma, X Chen - Food and Chemical Toxicology, 2021 - Elsevier
Chronic inflammation is crucial for the pathological process of tumors due to increasing the
infiltration of cytokines, growth factors, and chemokines to the tumor microenvironment …

T cells in idiopathic pulmonary fibrosis: crucial but controversial

L Deng, T Huang, L Zhang - Cell Death Discovery, 2023 - nature.com
Idiopathic pulmonary fibrosis (IPF) has been extensively studied in recent decades due to its
rising incidence and high mortality. Despite an abundance of research, the mechanisms …

Trajectory modeling of endothelial-to-mesenchymal transition reveals galectin-3 as a mediator in pulmonary fibrosis

W Jia, Z Wang, C Gao, J Wu, Q Wu - Cell Death & Disease, 2021 - nature.com
The endothelial-to-mesenchymal transition (EndMT) is an important source of fibrotic cells in
idiopathic pulmonary fibrosis (IPF). However, how endothelial cells (ECs) are activated and …

Nuclear factor-kappa B (NF-κB) inhibition as a therapeutic target for plant nutraceuticals in mitigating inflammatory lung diseases

KS Alharbi, O Afzal, I Kazmi, MAJ Shaikh… - Chemico-biological …, 2022 - Elsevier
Nutraceuticals are dietary supplements that are used to improve health, postpone aging,
prevent illnesses, and maintain the human body's correct functioning. Nutraceuticals are …

Molecular aspects and therapeutic implications of herbal compounds targeting different types of cancer

A Sharma, L Sharma, SK Nandy, N Payal, S Yadav… - Molecules, 2023 - mdpi.com
Due to genetic changes in DNA (deoxyribonucleic acid) sequences, cancer continues to be
the second most prevalent cause of death. The traditional target-directed approach, which is …