A review of Glycogen Synthase Kinase-3 (GSK3) inhibitors for cancers therapies
The intricate molecular pathways governing cancer development and progression have
spurred intensive investigations into novel therapeutic targets. Glycogen Synthase Kinase-3 …
spurred intensive investigations into novel therapeutic targets. Glycogen Synthase Kinase-3 …
[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis
J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …
with unknown causes. The incidence rate increases year by year and the prognosis is poor …
Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin
L Qin, N Liu, C Bao, D Yang, G Ma, W Yi… - Acta Pharmacologica …, 2023 - nature.com
Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …
Cancer metastasis as a non-healing wound
M Deyell, CS Garris, AM Laughney - British journal of cancer, 2021 - nature.com
Most cancer deaths are caused by metastasis: recurrence of disease by disseminated
tumour cells at sites distant from the primary tumour. Large numbers of disseminated tumour …
tumour cells at sites distant from the primary tumour. Large numbers of disseminated tumour …
Inflammation, fibrosis and cancer: mechanisms, therapeutic options and challenges
Simple Summary Inflammation is like the proverbial double-edged sword. Controlled short-
term inflammation could be a protective response while uncontrolled inflammation sustains …
term inflammation could be a protective response while uncontrolled inflammation sustains …
Anticancer and anti-inflammatory properties of mangiferin: A review of its molecular mechanisms
S Mei, H Ma, X Chen - Food and Chemical Toxicology, 2021 - Elsevier
Chronic inflammation is crucial for the pathological process of tumors due to increasing the
infiltration of cytokines, growth factors, and chemokines to the tumor microenvironment …
infiltration of cytokines, growth factors, and chemokines to the tumor microenvironment …
T cells in idiopathic pulmonary fibrosis: crucial but controversial
L Deng, T Huang, L Zhang - Cell Death Discovery, 2023 - nature.com
Idiopathic pulmonary fibrosis (IPF) has been extensively studied in recent decades due to its
rising incidence and high mortality. Despite an abundance of research, the mechanisms …
rising incidence and high mortality. Despite an abundance of research, the mechanisms …
Trajectory modeling of endothelial-to-mesenchymal transition reveals galectin-3 as a mediator in pulmonary fibrosis
W Jia, Z Wang, C Gao, J Wu, Q Wu - Cell Death & Disease, 2021 - nature.com
The endothelial-to-mesenchymal transition (EndMT) is an important source of fibrotic cells in
idiopathic pulmonary fibrosis (IPF). However, how endothelial cells (ECs) are activated and …
idiopathic pulmonary fibrosis (IPF). However, how endothelial cells (ECs) are activated and …
Nuclear factor-kappa B (NF-κB) inhibition as a therapeutic target for plant nutraceuticals in mitigating inflammatory lung diseases
Nutraceuticals are dietary supplements that are used to improve health, postpone aging,
prevent illnesses, and maintain the human body's correct functioning. Nutraceuticals are …
prevent illnesses, and maintain the human body's correct functioning. Nutraceuticals are …
Molecular aspects and therapeutic implications of herbal compounds targeting different types of cancer
A Sharma, L Sharma, SK Nandy, N Payal, S Yadav… - Molecules, 2023 - mdpi.com
Due to genetic changes in DNA (deoxyribonucleic acid) sequences, cancer continues to be
the second most prevalent cause of death. The traditional target-directed approach, which is …
the second most prevalent cause of death. The traditional target-directed approach, which is …