Dopamine, behavioral economics, and effort

JD Salamone, M Correa, AM Farrar… - Frontiers in behavioral …, 2009 - frontiersin.org
There are numerous problems with the hypothesis that brain dopamine (DA) systems,
particularly in the nucleus accumbens, directly mediate the rewarding or primary …

The behavioral pharmacology of effort‐related choice behavior: dopamine, adenosine and beyond

JD Salamone, M Correa, EJ Nunes… - Journal of the …, 2012 - Wiley Online Library
For many years, it has been suggested that drugs that interfere with dopamine (DA)
transmission alter the “rewarding” impact of primary reinforcers such as food. Research and …

The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences

JD Salamone, M Correa, S Yohn, LL Cruz… - Behavioural …, 2016 - Elsevier
This review paper is focused upon the involvement of mesolimbic dopamine (DA) and
related brain systems in effort-based processes. Interference with DA transmission affects …

Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression

EJ Nunes, PA Randall, EE Hart, C Freeland… - Journal of …, 2013 - Soc Neuroscience
Motivated behaviors are often characterized by a high degree of behavioral activation, and
work output and organisms frequently make effort-related decisions based upon cost/benefit …

Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl …

S Ferré, J Bonaventura, W Zhu… - Frontiers in …, 2018 - frontiersin.org
The central adenosine system and adenosine receptors play a fundamental role in the
modulation of dopaminergic neurotransmission. This is mostly achieved by the strategic co …

Xanthines as adenosine receptor antagonists

BB Fredholm, CE Müller, KA Jacobson - Methylxanthines, 2011 - Springer
The natural plant alkaloids caffeine and theophylline were the first adenosine receptor (AR)
antagonists described in the literature. They exhibit micromolar affinities and are non …

Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: effects of drugs acting on dopamine, adenosine, and muscarinic …

EJ Nunes, PA Randall, S Podurgiel, M Correa… - Neuroscience & …, 2013 - Elsevier
Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral
activation and effort-related processes. Although nucleus accumbens (NAc) DA depletions …

Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors

AM Farrar, KN Segovia, PA Randall, EJ Nunes… - Neuroscience, 2010 - Elsevier
Nucleus accumbens dopamine (DA) is a critical component of the brain circuitry regulating
work output in reinforcement-seeking behavior and effort-related choice behavior. Moreover …

Nucleus accumbens adenosine A2A receptors regulate exertion of effort by acting on the ventral striatopallidal pathway

S Mingote, L Font, AM Farrar, R Vontell… - Journal of …, 2008 - Soc Neuroscience
Goal-directed actions are sensitive to work-related response costs, and dopamine in
nucleus accumbens is thought to modulate the exertion of effort in motivated behavior …

The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit …

AM Mott, EJ Nunes, LE Collins, RG Port, KS Sink… - …, 2009 - Springer
Rationale Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating
behavioral activation and effort-related processes. Research involving choice tasks has …