P-glycoprotein in autoimmune rheumatic diseases

M García-Carrasco, C Mendoza-Pinto, SM Díaz… - Autoimmunity …, 2015 - Elsevier
P-glycoprotein (Pgp) is a transmembrane protein of 170 kD encoded by the multidrug
resistance 1 (MDR-1) gene, localized on chromosome 7. More than 50 polymorphisms of the …

Leukocytapheresis using a leukocyte removal filter

J Shirokaze - Therapeutic Apheresis, 2002 - Wiley Online Library
Leukocytapheresis (LCAP) long has been investigated with a leukocyte removal filter for the
treatment of various kinds of autoimmune related and inflammatory diseases such as …

Evaluation of filtration leucocytapheresis for use in the treatment of patients with rheumatoid arthritis

Y Ueki, S Yamasaki, Y Kanamoto, T Kawazu… - …, 2000 - academic.oup.com
Objectives. To evaluate the efficacy of filtration leucocytapheresis (LCP) for rheumatoid
arthritis (RA). Methods. LCP was carried out three times, with 1 week separating each …

Leukocytapheresis (LCAP) decreases the level of platelet-derived microparticles (MPs) and increases the level of granulocytes-derived MPs: a possible connection …

K Umekita, T Hidaka, S Ueno, I Takajo, Y Kai… - Modern …, 2009 - Taylor & Francis
Microparticles (MPs) are believed to play an important role in inflammatory diseases such as
rheumatoid arthritis (RA). Leukocytapheresis (LCAP) is one of the options available for the …

Leukocytapheresis in rheumatoid arthritis

T Hidaka, Y Hashiba, K Kubo, Y Kai… - Transfusion and Apheresis …, 2017 - Elsevier
In this article, we discussed leukocytapheresis (LCAP) for rheumatoid arthritis (RA).
Recently, a simple and practical on-line continuous LACP system has been developed. It is …

A case report: first case of filtration leukocytapheresis for a patient of aortitis syndrome associated with ulcerative colitis

K Fukunaga, K Sawada, Y Fukuda… - Therapeutic …, 2002 - Wiley Online Library
An 18‐year‐old woman was treated with leukocytapheresis (LCAP) for her combined
ulcerative colitis (UC) and aortitis syndrome (AS). Because a close relationship between …

Effect of filtration leukocytapheresis therapy: modulation of white blood cell enzyme activities in patients with rheumatoid arthritis

S Yamasaki, Y Ueki, H Nakamura, M Yano… - Artificial …, 2002 - Wiley Online Library
We treated 12 patients with rheumatoid arthritis by filtration leukocytapheresis (FLCP) and
evaluated its effect on leukocyte enzyme activities. We calculated the number of leukocytes …

A case report of leukocytapheresis for refractory leg ulcers complicated with rheumatoid arthritis

Y Itoh, Y Takeshita, Y Ozawa, S Tohma… - Therapeutic …, 2006 - Wiley Online Library
Leukocytapheresis (LCAP) has recently been investigated for the treatment of drug‐resistant
rheumatoid arthritis (RA). In the present clinical study, we used LCAP in three patients with …

Comparison of lymphocyte depletion and clinical effectiveness on filtration leukocytapheresis in patients with rheumatoid arthritis

Y Ueki, H Nakamura, Y Kanamoto… - Therapeutic …, 2001 - Wiley Online Library
We evaluated the relationship between the clinical benefit of filtration leukocytapheresis
(LCP) and the number of removed leukocytes in patients with rheumatoid arthritis (RA). LCP …

Poorly controlled ulcerative colitis treated by colectomy during remission induced by extracorporeal leukocyte removal therapy

K Fukunaga, Y Fukuda, K Sawada, K Hori… - Journal of …, 2003 - Springer
Both monocyte-granulocytapheresis (M-GCAP) and leukocytapheresis (LCAP) are
categorized as extracorporeal leukocyte removal therapies (ECCTs). These therapies have …