Precision medicine and radiogenomics in breast cancer: new approaches toward diagnosis and treatment

K Pinker, J Chin, AN Melsaether, EA Morris, L Moy - Radiology, 2018 - pubs.rsna.org
Precision medicine is medicine optimized to the genotypic and phenotypic characteristics of
an individual and, when present, his or her disease. It has a host of targets, including genes …

Background, current role, and potential applications of radiogenomics

K Pinker, F Shitano, E Sala, RK Do… - Journal of Magnetic …, 2018 - Wiley Online Library
With the genomic revolution in the early 1990s, medical research has been driven to study
the basis of human disease on a genomic level and to devise precise cancer therapies …

Intratumoral and peritumoral radiomics for the pretreatment prediction of pathological complete response to neoadjuvant chemotherapy based on breast DCE-MRI

NM Braman, M Etesami, P Prasanna, C Dubchuk… - Breast Cancer …, 2017 - Springer
Background In this study, we evaluated the ability of radiomic textural analysis of
intratumoral and peritumoral regions on pretreatment breast cancer dynamic contrast …

Association of peritumoral radiomics with tumor biology and pathologic response to preoperative targeted therapy for HER2 (ERBB2)–positive breast cancer

N Braman, P Prasanna, J Whitney, S Singh… - JAMA network …, 2019 - jamanetwork.com
Importance There has been significant recent interest in understanding the utility of
quantitative imaging to delineate breast cancer intrinsic biological factors and therapeutic …

Quantitative MRI radiomics in the prediction of molecular classifications of breast cancer subtypes in the TCGA/TCIA data set

H Li, Y Zhu, ES Burnside, E Huang, K Drukker… - NPJ breast …, 2016 - nature.com
Using quantitative radiomics, we demonstrate that computer-extracted magnetic resonance
(MR) image-based tumor phenotypes can be predictive of the molecular classification of …

A machine learning approach to radiogenomics of breast cancer: a study of 922 subjects and 529 DCE-MRI features

A Saha, MR Harowicz, LJ Grimm, CE Kim… - British journal of …, 2018 - nature.com
Background Recent studies showed preliminary data on associations of MRI-based imaging
phenotypes of breast tumours with breast cancer molecular, genomic, and related …

Radiomics signature on magnetic resonance imaging: association with disease-free survival in patients with invasive breast cancer

H Park, Y Lim, ES Ko, H Cho, JE Lee, BK Han… - Clinical Cancer …, 2018 - AACR
Purpose: To develop a radiomics signature based on preoperative MRI to estimate disease-
free survival (DFS) in patients with invasive breast cancer and to establish a radiomics …

Deep learning for identifying radiogenomic associations in breast cancer

Z Zhu, E Albadawy, A Saha, J Zhang… - Computers in biology …, 2019 - Elsevier
Rationale and objectives To determine whether deep learning models can distinguish
between breast cancer molecular subtypes based on dynamic contrast-enhanced magnetic …

Radiomic analysis in contrast-enhanced spectral mammography for predicting breast cancer histological outcome

D La Forgia, A Fanizzi, F Campobasso, R Bellotti… - Diagnostics, 2020 - mdpi.com
Contrast-Enhanced Spectral Mammography (CESM) is a recently introduced
mammographic method with characteristics particularly suitable for breast cancer radiomic …

Radiomic analysis reveals DCE-MRI features for prediction of molecular subtypes of breast cancer

M Fan, H Li, S Wang, B Zheng, J Zhang, L Li - PloS one, 2017 - journals.plos.org
The purpose of this study was to investigate the role of features derived from breast dynamic
contrast-enhanced magnetic resonance imaging (DCE-MRI) and to incorporated clinical …