Key challenges in providing effective antibiotic therapy for critically ill patients with bacterial sepsis and septic shock
CB Landersdorfer, RL Nation - Clinical Pharmacology & …, 2021 - Wiley Online Library
Early initiation of effective antibiotic therapy is vitally important for saving the lives of critically
ill patients with sepsis or septic shock. The susceptibility of the infecting pathogen and the …
ill patients with sepsis or septic shock. The susceptibility of the infecting pathogen and the …
Population pharmacokinetics and pharmacodynamics of piperacillin in critically ill patients during the early phase of sepsis
W Sukarnjanaset, S Jaruratanasirikul… - … of Pharmacokinetics and …, 2019 - Springer
This study aimed to characterize the population pharmacokinetics (PKs) of piperacillin and
investigate probability of target attainment (PTA) and cumulative fraction of response (CFR) …
investigate probability of target attainment (PTA) and cumulative fraction of response (CFR) …
Population pharmacokinetics of piperacillin/tazobactam in critically ill Korean patients and the effects of extracorporeal membrane oxygenation
YK Kim, HS Kim, S Park, H Kim… - Journal of …, 2022 - academic.oup.com
Objectives To explore extracorporeal membrane oxygenation (ECMO)-related alterations of
the pharmacokinetics (PK) of piperacillin/tazobactam and determine an optimal dosage …
the pharmacokinetics (PK) of piperacillin/tazobactam and determine an optimal dosage …
Scaling beta‐lactam antimicrobial pharmacokinetics from early life to old age
DO Lonsdale, EH Baker, K Kipper… - British journal of …, 2019 - Wiley Online Library
Aims Beta‐lactam dose optimization in critical care is a current priority. We aimed to review
the pharmacokinetics (PK) of three commonly used beta‐lactams (amoxicillin±clavulanate …
the pharmacokinetics (PK) of three commonly used beta‐lactams (amoxicillin±clavulanate …
[HTML][HTML] Optimal antipseudomonal ꞵ-lactam drug dosing recommendations in critically-ill Asian patients receiving CRRT
Introduction The average body weight is smaller in Asian patients compared with Western
patients, but influence of body weight in antibiotic dosing is unknown. This study was to …
patients, but influence of body weight in antibiotic dosing is unknown. This study was to …
Population pharmacokinetic modeling and pharmacodynamic target attainment simulation of piperacillin/tazobactam for dosing optimization in late elderly patients …
N Ishihara, N Nishimura, K Ikawa, F Karino, K Miura… - Antibiotics, 2020 - mdpi.com
The aim of this study was to develop a population pharmacokinetic model for piperacillin
(PIPC)/tazobactam (TAZ) in late elderly patients with pneumonia and to optimize the …
(PIPC)/tazobactam (TAZ) in late elderly patients with pneumonia and to optimize the …
Population pharmacokinetic analysis of meropenem after intravenous infusion in Korean patients with acute infections
YK Kim, DH Lee, J Jeon, HJ Jang, HK Kim, K Jin… - Clinical …, 2018 - Elsevier
Purpose The aim of this study was to investigate the population pharmacokinetic (PK) profile
of meropenem in Korean patients with acute infections. Methods The study included 37 …
of meropenem in Korean patients with acute infections. Methods The study included 37 …
Collaborative Pharmacokinetic–Pharmacodynamic Research for Optimization of Antimicrobial Therapy
S Han - Infection & Chemotherapy, 2016 - synapse.koreamed.org
The individualization of antimicrobial therapy has long been of major interest to infectious
disease physicians [1]. Individualization of dosage regimens includes consideration of the …
disease physicians [1]. Individualization of dosage regimens includes consideration of the …