Cross-validation (CV) is a resampling approach to evaluate machine learning models when
sample size is limited. The number of all possible combinations of folds for the training data …

Amyloid-β (A β) is the target in many clinical trials for Alzheimer's disease (AD). Preclinical
AD patients are heterogeneous with regards to different backgrounds and diagnosis …

Biomedical studies, such as clinical trials, often require the comparison of measurements
from two correlated tests in which each unit of observation is associated with a binary …

Psychiatric and substance use disorders frequently coexist and require co-management, yet
little is known about the prevalence of psychiatric disorders among patients maintained on …

Restricted mean survival time is an alternative measure of treatment effect to hazard ratio in
clinical trials with time-to-event outcome. The current methods have been focused on one …

Introduction Transfusions in surgery can be life-saving interventions, but inappropriate
transfusions may lack clinical benefit and cause harm. Transfusion decision-making in …

Repeated data are increasingly collected in studies to investigate the trajectory of change in
measurements over time. Determining a link between one repeated measurement with …

Interval-censored data occur in a study where the exact event time of each participant is not
observed but it is known to be within a certain time interval. Multiple tests were proposed for …

For paired binary data, the hybrid method and the score method are often recommended for
use to calculate the confidence interval for risk difference. These asymptotic intervals do not …

Confidence interval for the difference of two proportions has been studied for decades. Many
methods were developed to improve the approximation of the limiting distribution of test …