Intracellular processing of vitamin B12 by MMACHC (CblC)
L Hannibal, DW Jacobsen - Vitamins and hormones, 2022 - Elsevier
Abstract Vitamin B 12 (cobalamin, Cbl, B 12) is a water-soluble micronutrient synthesized
exclusively by a group of microorganisms. Human beings are unable to make B 12 and thus …
exclusively by a group of microorganisms. Human beings are unable to make B 12 and thus …
Versatile enzymology and heterogeneous phenotypes in cobalamin complementation type C disease
AJ Esser, S Mukherjee, IA Dereven'kov, SV Makarov… - Iscience, 2022 - cell.com
Nutritional deficiency and genetic errors that impair the transport, absorption, and utilization
of vitamin B 12 (B 12) lead to hematological and neurological manifestations. The cblC …
of vitamin B 12 (B 12) lead to hematological and neurological manifestations. The cblC …
Thiolatocobalamins repair the activity of pathogenic variants of the human cobalamin processing enzyme CblC
V Wingert, S Mukherjee, AJ Esser, S Behringer… - Biochimie, 2021 - Elsevier
Thiolatocobalamins are a class of cobalamins comprised of naturally occurring and synthetic
ligands. Glutathionylcobalamin (GSCbl) occurs naturally in mammalian cells, and also as an …
ligands. Glutathionylcobalamin (GSCbl) occurs naturally in mammalian cells, and also as an …
Alzheimer's amyloidopathy: an alternative aspect
B Regland, A McCaddon - Journal of Alzheimer's Disease, 2019 - content.iospress.com
The 'amyloid hypothesis' dominates Alzheimer's disease (AD) research but has failed to
deliver effective therapies. Amyloid precursor protein (APP) and presenilin-1 (PSEN1) …
deliver effective therapies. Amyloid precursor protein (APP) and presenilin-1 (PSEN1) …