Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …

Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Cellular senescence is the inability of cells to proliferate, which has both beneficial and
detrimental effects on tissue development and homeostasis. Chronic accumulation of …

Mesenchymal stromal cells (MSCs) are currently widely used in cell based therapy
regarding to their remarkable efficacy in controlling the inflammatory status in patients …

Simple Summary Aging and frailty are complex processes implicating multifactorial
mechanisms, which demand for new therapeutic strategies against their devastating effects …

Improving health and delaying aging is the focus of medical research. Previous studies have
shown that mesenchymal stem cell (MSC) senescence is closely related to organic aging …

Osteoarthritis (OA) has been recognized as an age-related degenerative disease commonly
seen in the elderly that affects the whole “organ” including cartilage, subchondral bone …

Mesenchymal stem/stromal cells (MSCs) are a reservoir for tissue homeostasis and repair
that age during organismal aging. Beside the fundamental in vivo role of MSCs, they have …

Bone changes have always been the focus of research on osteoarthritis, but the number of
studies on synovitis has increased only over the last 10 years. Our current understanding is …

Bone metabolism is regulated by osteoblasts, osteoclasts, osteocytes, and stem cells.
Pathologies such as osteoporosis, osteoarthritis, osteonecrosis, and traumatic fractures …