A comprehensive review on the role of the gut microbiome in human neurological disorders

SG Sorboni, HS Moghaddam… - Clinical microbiology …, 2022 - Am Soc Microbiol
The human body is full of an extensive number of commensal microbes, consisting of
bacteria, viruses, and fungi, collectively termed the human microbiome. The initial …

Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions

X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Parkinson's disease in women and men: what's the difference?

S Cerri, L Mus, F Blandini - Journal of Parkinson's disease, 2019 - content.iospress.com
Increasing evidence points to biological sex as an important factor in the development and
phenotypical expression of Parkinson's disease (PD). Risk of developing PD is twice as high …

Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases

AG Wu, XG Zhou, G Qiao, LU Yu, Y Tang, LU Yan… - Ageing research …, 2021 - Elsevier
Neuroinflammation is considered as a detrimental factor in neurodegenerative diseases,
including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) …

Parkinson's disease: A review

DM Radhakrishnan, V Goyal - Neurology India, 2018 - journals.lww.com
Parkinson's disease is a common movement disorder seen in neurological practice, but the
diagnosis and management is challenging. The diagnosis is clinical and sometimes difficult …

The evolving landscape of exosomes in neurodegenerative diseases: exosomes characteristics and a promising role in early diagnosis

S Rastogi, V Sharma, PS Bharti, K Rani… - International journal of …, 2021 - mdpi.com
Neurodegenerative diseases (ND) remains to be one of the biggest burdens on healthcare
systems and serves as a leading cause of disability and death. Alzheimer's disease (AD) is …

Epidemiology and etiology of Parkinson's disease: a review of the evidence

K Wirdefeldt, HO Adami, P Cole, D Trichopoulos… - European journal of …, 2011 - Springer
The etiology of Parkinson's disease (PD) is not well understood but likely to involve both
genetic and environmental factors. Incidence and prevalence estimates vary to a large …

Sex differences in neurodevelopmental and neurodegenerative disorders: focus on microglial function and neuroinflammation during development

R Hanamsagar, SD Bilbo - The Journal of steroid biochemistry and …, 2016 - Elsevier
Several neurological conditions are associated with sex differences in prevalence or
outcome. For example, autism predominantly affects boys, depression is more common in …

Parkinson disease

W Poewe, K Seppi, CM Tanner, GM Halliday… - Nature reviews Disease …, 2017 - nature.com
Parkinson disease is the second-most common neurodegenerative disorder that affects 2–
3% of the population≥ 65 years of age. Neuronal loss in the substantia nigra, which causes …

[HTML][HTML] Sex differences in Parkinson's disease

GE Gillies, IS Pienaar, S Vohra, Z Qamhawi - Frontiers in …, 2014 - Elsevier
Parkinson's disease (PD) displays a greater prevalence and earlier age at onset in men.
This review addresses the concept that sex differences in PD are determined, largely, by …