Psychosis in Alzheimer disease—mechanisms, genetics and therapeutic opportunities
Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …
safe and effective treatments are available. However, new approaches to symptom …
Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings
Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia
We performed a systematic analysis of blood DNA methylation profiles from 4483
participants from seven independent cohorts identifying differentially methylated positions …
participants from seven independent cohorts identifying differentially methylated positions …
Epigenetic modifications in schizophrenia and related disorders: molecular scars of environmental exposures and source of phenotypic variability
J Richetto, U Meyer - Biological Psychiatry, 2021 - Elsevier
Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …
pathophysiology of schizophrenia and other psychiatric disorders with developmental …
Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer's disease
DNA methylation differences in Alzheimer's disease (AD) have been reported. Here, we
conducted a meta-analysis of more than 1000 prefrontal cortex brain samples to prioritize …
conducted a meta-analysis of more than 1000 prefrontal cortex brain samples to prioritize …
Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets
V Micale, M Di Bartolomeo, S Di Martino, T Stark… - Pharmacology & …, 2023 - Elsevier
The etiopathogenesis of mental disorders is not fully understood and accumulating evidence
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …
Hidden role of gut microbiome dysbiosis in schizophrenia: Antipsychotics or psychobiotics as therapeutics?
N Munawar, K Ahsan, K Muhammad, A Ahmad… - International journal of …, 2021 - mdpi.com
Schizophrenia is a chronic, heterogeneous neurodevelopmental disorder that has complex
symptoms and uncertain etiology. Mounting evidence indicates the involvement of genetics …
symptoms and uncertain etiology. Mounting evidence indicates the involvement of genetics …
Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability
LF Rizzardi, PF Hickey, V Rodriguez DiBlasi… - Nature …, 2019 - nature.com
Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal
and abnormal brain function involve specialized brain regions. We examined DNA …
and abnormal brain function involve specialized brain regions. We examined DNA …
Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
Background People with neurodegenerative disorders show diverse clinical syndromes,
genetic heterogeneity, and distinct brain pathological changes, but studies report overlap …
genetic heterogeneity, and distinct brain pathological changes, but studies report overlap …
Polygenic risk scores in clinical psychology: bridging genomic risk to individual differences
R Bogdan, DAA Baranger… - Annual review of clinical …, 2018 - annualreviews.org
Genomewide association studies (GWASs) across psychiatric phenotypes have shown that
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …