Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Alzheimer's disease (AD) is caused by synaptic and neuronal loss in the brain. One of the
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …

The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …

Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐
translational modification that controls levels and function of hundreds of membrane …

Aberrant cleavage of Notch by γ-secretase leads to several types of cancer, but how γ-
secretase recognizes its substrate remains unknown. Here we report the cryo-electron …

Development of γ-secretase inhibitors (GSIs) and modulators (GSMs) represents an
attractive therapeutic opportunity for Alzheimer's disease (AD) and cancers. However, how …

Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …

The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to
the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form …

Alzheimer's disease (AD) is the most common cause of dementia, affecting millions of
people worldwide, and no cure is currently available. The major pathological hallmarks of …

γ-secretase is responsible for the proteolysis of amyloid precursor protein (APP) into short,
aggregation-prone amyloid-beta (Aβ) peptides, which are centrally implicated in the …