ABSTRACT Toll-like receptor 3 (TLR3) is a pattern recognition receptor that senses
exogenous (viral) as well as endogenous (mammalian) double-stranded RNA in …

Over the last three decades, the combination of a sedentary lifestyle and excessive food
intake has led to a significant increase in the prevalence of obesity. The latter favors a …

Background/Aims: Diabetic subjects are more susceptible to infections, which is partially due
to insulin deficiency and hyperglycemia. We hypothesized that insulin influences cytokine …

Type 2 diabetes mellitus confers a threefold increased risk for tuberculosis, but the
underlying immunological mechanisms are still largely unknown. Possible mediators of this …

Heart failure (HF) represents a major public health burden. Inflammation has been shown to
be a critical factor in the progression of HF, regardless of the aetiology. Disappointingly, the …

Porphyromonas gingivalis, a keystone oral pathogen implicated in development and
progression of periodontitis, may also contribute to the pathogenicity of diseases such as …

Chicken macrophages express several receptors for recognition of pathogens, including Toll-
like receptors (TLRs). TLRs bind to pathogen-associated molecular patterns (PAMPs) …

Accumulating evidence has shown that preeclampsia (PE) was associated with an aberrant
maternal-fetal inflammatory response. In the present study, we first found that in human PE …

The majority of cancer patients are among aged population, suggesting an urgent need to
advance our knowledge on complicated relationship between aging and cancer. It has been …

Background MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs
and IL-1 receptor and regulates innate immune response. However, it was not clear whether …