Cytochrome P450 structure, function and clinical significance: a review
P Manikandan, S Nagini - Current drug targets, 2018 - ingentaconnect.com
Background: The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins
that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and …
that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and …
DNA methyltransferases: a novel target for prevention and therapy
Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …
agents, and the use of various therapeutic combinations, none of the available treatment …
Histone-deacetylase inhibitors: novel drugs for the treatment of cancer
RW Johnstone - Nature reviews Drug discovery, 2002 - nature.com
The opposing actions of histone acetyltransferases (HATs) and histone deacetylases
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …
Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects
M Ingelman-Sundberg, SC Sim, A Gomez… - Pharmacology & …, 2007 - Elsevier
The polymorphic nature of the cytochrome P450 (CYP) genes affects individual drug
response and adverse reactions to a great extent. This variation includes copy number …
response and adverse reactions to a great extent. This variation includes copy number …
Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9
DM Sapozhnikov, M Szyf - Nature Communications, 2021 - nature.com
Despite four decades of research to support the association between DNA methylation and
gene expression, the causality of this relationship remains unresolved. Here, we reaffirm that …
gene expression, the causality of this relationship remains unresolved. Here, we reaffirm that …
Epigenetic regulation and chromatin remodeling in learning and memory
S Kim, BK Kaang - Experimental & molecular medicine, 2017 - nature.com
Understanding the underlying mechanisms of memory formation and maintenance has been
a major goal in the field of neuroscience. Memory formation and maintenance are tightly …
a major goal in the field of neuroscience. Memory formation and maintenance are tightly …
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells
MF Robert, S Morin, N Beaulieu, F Gauthier, IC Chute… - Nature …, 2003 - nature.com
Transcriptional silencing by CpG island methylation is a prevalent mechanism of tumor-
suppressor gene suppression in cancers 1, 2, 3, 4. Genetic experiments have defined the …
suppressor gene suppression in cancers 1, 2, 3, 4. Genetic experiments have defined the …
The many faces of histone lysine methylation
M Lachner, T Jenuwein - Current opinion in cell biology, 2002 - Elsevier
Diverse post-translational modifications of histone amino termini represent an important
epigenetic mechanism for the organisation of chromatin structure and the regulation of gene …
epigenetic mechanism for the organisation of chromatin structure and the regulation of gene …
Epigenetics and human disease: translating basic biology into clinical applications
D Rodenhiser, M Mann - Cmaj, 2006 - Can Med Assoc
Epigenetics refers to the study of heritable changes in gene expression that occur without a
change in DNA sequence. Research has shown that epigenetic mechanisms provide an" …
change in DNA sequence. Research has shown that epigenetic mechanisms provide an" …
Epigenetic regulation of HIV-1 latency by cytosine methylation
SE Kauder, A Bosque, A Lindqvist, V Planelles… - PLoS …, 2009 - journals.plos.org
Human immunodeficiency virus type 1 (HIV-1) persists in a latent state within resting CD4+ T
cells of infected persons treated with highly active antiretroviral therapy (HAART). This …
cells of infected persons treated with highly active antiretroviral therapy (HAART). This …