[HTML][HTML] Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future
Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
Targeting epigenetics: A novel promise for Alzheimer's disease treatment
D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
[HTML][HTML] Curcumin mitigates the high-fat high-sugar diet-induced impairment of spatial memory, hepatic metabolism, and the alteration of the gut microbiome in …
The escalating prevalence of metabolic diseases and an aging demographic has been
correlated with a concerning rise in Alzheimer's disease (AD) incidence. This study aimed to …
correlated with a concerning rise in Alzheimer's disease (AD) incidence. This study aimed to …
[HTML][HTML] Traumatic brain injury induces an adaptive immune response in the meningeal transcriptome that is amplified by aging
Traumatic Brain Injury (TBI) is a major cause of disability and mortality, particularly among
the elderly, yet our mechanistic understanding of how age renders the post-traumatic brain …
the elderly, yet our mechanistic understanding of how age renders the post-traumatic brain …
Clusterin is a potential therapeutic target in Alzheimer's disease
N Palihati, Y Tang, Y Yin, D Yu, G Liu, Z Quan… - Molecular …, 2024 - Springer
In recent years, Clusterin, a glycosylated protein with multiple biological functions, has
attracted extensive research attention. It is closely associated with the physiological and …
attracted extensive research attention. It is closely associated with the physiological and …
Neuroprotective effects of gemfibrozil in neurological disorders: Focus on inflammation and molecular mechanisms
Abstract Background Gemfibrozil (Gem) is a drug that has been shown to activate PPAR‐α,
a nuclear receptor that plays a key role in regulating lipid metabolism. Gem is used to lower …
a nuclear receptor that plays a key role in regulating lipid metabolism. Gem is used to lower …
[HTML][HTML] The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
J He, F Liu, T Xu, J Ma, H Yu, J Zhao, Y Xie… - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder predominantly
affecting the elderly. While conventional pharmacological therapies remain the primary …
affecting the elderly. While conventional pharmacological therapies remain the primary …
Microbial infection promotes amyloid pathology in a mouse model of Alzheimer's disease via modulating γ-secretase
M Zhao, G Ma, X Yan, X Li, E Wang, XX Xu… - Molecular …, 2024 - nature.com
Microbial infection as a type of environmental risk factors is considered to be associated with
long-term increased risk of dementia, including Alzheimer's disease (AD). AD is …
long-term increased risk of dementia, including Alzheimer's disease (AD). AD is …
[HTML][HTML] The epigenetics of migraine
F Zobdeh, II Eremenko, MA Akan, VV Tarasov… - International Journal of …, 2023 - mdpi.com
Migraine is a complex neurological disorder and a major cause of disability. A wide range of
different drug classes such as triptans, antidepressants, anticonvulsants, analgesics, and …
different drug classes such as triptans, antidepressants, anticonvulsants, analgesics, and …
Antioxidant, anti‐inflammatory and epigenetic potential of curcumin in Alzheimer's disease
T Abdul‐Rahman, WA Awuah, T Mikhailova… - …, 2024 - Wiley Online Library
Alzheimer's disease (AD) constitutes a multifactorial neurodegenerative pathology
characterized by cognitive deterioration, personality alterations, and behavioral shifts. The …
characterized by cognitive deterioration, personality alterations, and behavioral shifts. The …