Deficiency or inhibition of lysophosphatidic acid receptor 1 protects against hyperoxia‐induced lung injury in neonatal rats

X Chen, FJ Walther, R Van Boxtel… - Acta …, 2016 - Wiley Online Library
Aim Blocking of lysophosphatidic acid (LPA) receptor (LPAR) 1 may be a novel therapeutic
option for bronchopulmonary dysplasia (BPD) by preventing the LPAR 1‐mediated adverse …

A Nomogram Based on Apelin‐12 for the Prediction of Major Adverse Cardiovascular Events after Percutaneous Coronary Intervention among Patients with ST …

E Zhao, H Xie, Y Zhang - Cardiovascular Therapeutics, 2020 - Wiley Online Library
Objective. This study aimed to establish a clinical prognostic nomogram for predicting major
adverse cardiovascular events (MACEs) after primary percutaneous coronary intervention …

Apelin improves cardiac function mainly through peripheral vasodilation in a mouse model of dilated cardiomyopathy

B El Mathari, P Briand, A Corbier, B Poirier, V Briand… - Peptides, 2021 - Elsevier
There is growing evidence that apelin plays a role in the regulation of the cardiovascular
system by increasing myocardial contractility and acting as a vasodilator. However, it …

[HTML][HTML] Mild exercise along with limb blood-flow restriction modulates the electrocardiogram, angiotensin, and apelin receptors of the heart in aging rats

A Raji-Amirhasani, S Joukar… - Iranian Journal of …, 2018 - ncbi.nlm.nih.gov
Objective (s): Considering the lack of information, the effects of mild endurance exercise plus
blood flow restriction (BFR) on electrocardiographic parameters, hypertrophy index, and …

Hydration-sensitive gene expression in brain

C Tang, C Zelenak, J Völkl, M Eichenmüller… - Cellular Physiology and …, 2011 - karger.com
Dehydration has a profound influence on neuroexcitability. The mechanisms remained,
however, incompletely understood. The present study addressed the effect of water …

[HTML][HTML] In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation …

D Nyimanu, RG Kay, RE Kuc, AJH Brown, FM Gribble… - Peptides, 2021 - Elsevier
Abstract Background Elabela/Toddler (ELA) is a novel endogenous ligand of the apelin
receptor, whose signalling has emerged as a therapeutic target, for example, in …

[HTML][HTML] Apelin-36-[L28A] and Apelin-36-[L28C (30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor

D Nyimanu, RE Kuc, TL Williams, M Bednarek… - Peptides, 2019 - Elsevier
Background Apelin signalling pathways have important cardiovascular and metabolic
functions. Recently, apelin-36-[L28A] and apelin-36-[L28C (30kDa-PEG)], were reported to …

Susceptibility to high-altitude pulmonary edema is associated with circulating miRNA levels under hypobaric hypoxia conditions

P Alam, G Agarwal, R Kumar… - … of Physiology-Lung …, 2020 - journals.physiology.org
Hypobaric hypoxia poses stress to sojourners traveling to high-altitude. A cascade of
physiological changes occurs to cope with or adapt to hypobaric hypoxia. However, an …

Enhanced expressions of apelin on proliferative hepatic arterial capillaries in human cirrhotic liver

H Yokomori, M Oda, K Yoshimura… - Hepatology Research, 2012 - Wiley Online Library
Aim: Apelin (APLN), the endogenous ligand of angiotensin‐like receptor 1 (APJ), is a
peptide necessary for embryonic and tumor angiogenesis. Little is known about the …

Participation of the nitric oxide pathway in lordosis induced by apelin-13 in female rats

A Luna-Hernández, M García-Juárez… - Hormones and …, 2023 - Elsevier
The present study investigated the participation of the nitric oxide pathway in facilitating
lordosis behavior induced by intrahypothalamic administration of apelin-13 in …