The JAK/STAT signaling pathway is an universally expressed intracellular signal
transduction pathway and involved in many crucial biological processes, including cell …

Cytokine signaling represents one of the cornerstones of the immune system, mediating the
complex responses required to facilitate appropriate immune cell development and function …

The JAK–STAT signal transduction pathway is responsible for mediating signals of over fifty
cytokines, growth factors and hormones. Signaling through the JAK–STAT pathway is …

Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune
system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well …

Autoimmune diseases are immune disorders characterized by T cell hyperactivity and B cell
overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of …

Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives
many of the cancer 'hallmarks' through downstream activation of the Janus kinase/signal …

Inflammation is a physiological mechanism used by organisms to defend themselves
against infection, restoring homeostasis in damaged tissues. It represents the starting point …

Simple Summary Due to the broad functions of Toll-like receptor 2 (TLR2) in innate
immunity, the drive for the development of TLR2-targeted therapeutic treatments has …

The host immune system has multiple innate immune receptors that can identify, distinguish
and react to viral infections. In innate immune response, the host recognizes pathogen …

Cardiovascular disease (CVD) remains a leading cause of mortality and morbidity
worldwide. Numerous therapies are currently under investigation to improve pathological …