Septins are an integral component of the cytoskeleton, assembling into higher-order
oligomers and filamentous polymers that associate with actin filaments, microtubules and …

Septins belong to a family of proteins that is highly conserved in eukaryotes and is
increasingly recognized as a novel component of the cytoskeleton. All septins are GTP …

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …

Numerous physiological and pathological stimuli promote the rearrangement of the actin
cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively …

The suppressor of cytokine signalling (SOCS) proteins were, as their name suggests, first
described as inhibitors of cytokine signalling. While their actions clearly now extend to other …

The network of actin filaments is one of the crucial cytoskeletal structures contributing to the
morphological framework of a cell and which participates in the dynamic regulation of …

ATR controls chromosome integrity and chromatin dynamics. We have previously shown
that yeast Mec1/ATR promotes chromatin detachment from the nuclear envelope to …

Cell polarity relies on the asymmetric organization of cellular components and structures.
Actin and microtubules are well suited to provide the structural basis for cell polarization …

Cytokines are key modulators of T cell biology, but their influence can be attenuated by
suppressors of cytokine signaling (SOCS), a family of proteins consisting of eight members …

Cytokine and growth factor signaling mediates essential roles in the differentiation,
proliferation, survival and function of a number of cell lineages. This is achieved via specific …