Maintaining mitochondrial health is emerging as a keystone in aging and associated
diseases. The selective degradation of mitochondria by mitophagy is of particular …

Lysosomes catabolize and recycle lipids and other biological molecules to maintain cellular
homeostasis in diverse nutrient environments. Lysosomal lipid catabolism relies on the …

Inherited retinal degeneration (RD) leads to the impairment or loss of vision in millions of
individuals worldwide, most frequently due to the loss of photoreceptor (PR) cells. Animal …

Lysosomes are central organelles for cellular degradation and energy metabolism.
Neuronal ceroid lipofuscinoses (NCLs) are a group of the most common neurodegenerative …

Homozygous mutations in the progranulin gene (GRN) are associated with neuronal ceroid
lipofuscinosis 11 (CLN11), a rare lysosomal-storage disorder characterized by cerebellar …

Lysosomal storage diseases (LSDs) comprise a group of inherited monogenic disorders
characterized by lysosomal dysfunctions due to undegraded substrate accumulation. They …

This review discusses how lipophagy and cytosolic lipolysis degrade cellular lipids, as well
as how these pathway ys communicate, how they affect lipid metabolism and energy …

The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative
lysosomal storage disorders (LSDs), traditionally grouped together based on shared clinical …

Mutation of the Wiskott–Aldrich syndrome protein and SCAR homology (WASH) complex
subunit, SWIP, is implicated in human intellectual disability, but the cellular etiology of this …

The value of pH in various parts of protoplasm can affect nearly all aspects of cell functions.
Therefore, the determination of intracellular acid-base features is required in many areas of …