[HTML][HTML] Drugging p53 in cancer: one protein, many targets
Mutations in the TP53 tumour suppressor gene are very frequent in cancer, and attempts to
restore the functionality of p53 in tumours as a therapeutic strategy began decades ago …
restore the functionality of p53 in tumours as a therapeutic strategy began decades ago …
[HTML][HTML] AAV vectors: The Rubik's cube of human gene therapy
A Pupo, A Fernández, SH Low, A François… - Molecular Therapy, 2022 - cell.com
Defective genes account for∼ 80% of the total of more than 7,000 diseases known to date.
Gene therapy brings the promise of a one-time treatment option that will fix the errors in …
Gene therapy brings the promise of a one-time treatment option that will fix the errors in …
[HTML][HTML] Gene therapy clinical trials, where do we go? An overview
There have been many ups and downs since the introduction of gene therapy as a
therapeutic modality for diseases. However, the journey of gene therapy has reached a …
therapeutic modality for diseases. However, the journey of gene therapy has reached a …
[HTML][HTML] Non-viral vectors in gene therapy: recent development, challenges, and prospects
H Zu, D Gao - The AAPS journal, 2021 - Springer
Gene therapy has been experiencing a breakthrough in recent years, targeting various
specific cell groups in numerous therapeutic areas. However, most recent clinical studies …
specific cell groups in numerous therapeutic areas. However, most recent clinical studies …
Gene therapy: Comprehensive overview and therapeutic applications
Gene therapy is the product of man's quest to eliminate diseases. Gene therapy has three
facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where …
facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where …
[HTML][HTML] CRISPR gene therapy: applications, limitations, and implications for the future
A series of recent discoveries harnessing the adaptive immune system of prokaryotes to
perform targeted genome editing is having a transformative influence across the biological …
perform targeted genome editing is having a transformative influence across the biological …
Viral vector‐based gene therapies in the clinic
Gene therapies are currently one of the most investigated therapeutic modalities in both the
preclinical and clinical settings and have shown promise in treating a diverse spectrum of …
preclinical and clinical settings and have shown promise in treating a diverse spectrum of …
Polymeric delivery of therapeutic nucleic acids
R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
[HTML][HTML] Localized interleukin-12 for cancer immunotherapy
KG Nguyen, MR Vrabel, SM Mantooth… - Frontiers in …, 2020 - frontiersin.org
Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …
[HTML][HTML] Emerging applications of nanotechnology in healthcare systems: Grand challenges and perspectives
Healthcare, as a basic human right, has often become the focus of the development of
innovative technologies. Technological progress has significantly contributed to the …
innovative technologies. Technological progress has significantly contributed to the …