The application of Raman spectroscopic methods in life science applications has entered a
new era due to advances in instrumentation, miniaturization and, most importantly …

The CRISPR genome editing technology has revolutionized the way gene function is
studied. Genome editing can be achieved in single genes or for thousands of genes …

Understanding the basis for cellular growth, proliferation, and function requires determining
the roles of essential genes in diverse cellular processes, including visualizing their …

The infection of mammalian cells by viruses and innate immune responses to infection are
spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation …

Spatial structure in biology, spanning molecular, organellular, cellular, tissue, and
organismal scales, is encoded through a combination of genetic and epigenetic factors in …

Measuring single cell responses to the universe of chemicals (drugs, natural products,
environmental toxicants etc.) is of paramount importance to human health as phenotypic …

The clustered regularly interspaced short palindromic repeats (CRISPR)‐based genetic
screening has been demonstrated as a powerful approach for unbiased functional genomics …

Pooled optical screens have enabled the study of cellular interactions, morphology, or
dynamics at massive scale, but have not yet leveraged the power of highly-plexed single …

CRISPR screening is a powerful tool that links specific genetic alterations to corresponding
phenotypes, thus allowing for high-throughput identification of novel gene functions. Pooled …

Accurately quantifying cellular morphology at scale could substantially empower existing
single-cell approaches. However, measuring cell morphology remains an active field of …