Globally, 50 million people live with dementia, with Alzheimer disease (AD) being
responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia …

Alzheimer's disease (AD) is a biologically complex neurodegenerative dementia. Nearly 20
years ago, with the combination of observations from biochemistry, neuropathology and …

The amyloid hypothesis (AH) is still the most accepted model to explain the pathogenesis of
inherited Alzheimer's disease (IAD). However, despite the neuropathological overlapping …

Alzheimer's disease (AD) is the most common form of dementia. The risk of AD increases
with age. Although two of the main pathological features of AD, amyloid plaques and …

Many have criticized the amyloid cascade hypothesis of Alzheimer's disease for its
inconsistencies and failures to either accurately predict disease symptoms or guide the …

Many models of disease progression in Alzheimer's disease (AD) have been proposed to
help guide experimental design and aid the interpretation of results. Models focussing on …

Background: Alzheimer's disease (AD) is the leading cause of dementia. With no reliable
treatment that delays or reverses the progress of AD, effective medical drugs, and …

The term Western diet (WD) describes the consumption of large amounts of highly
processed foods, rich in simple sugars and saturated fats. Long-term WD feeding leads to …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline
that afflicts as many as 45% of individuals who survive past the age of 85. AD has been …

The autophagy process is the major cellular degradation pathway for long-lived proteins and
organelles. Dysfunction of autophagy may lead to several neurodegenerative disorders …