Prevalence of diabetes, a serious public health problem is rapidly increasing worldwide.
Type-2 diabetes is the common form of diabetes characterized by insulin resistance and …

In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30%
glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase (AR) …

Streptozotocin (STZ) has been extensively used over the last three decades to induce
diabetes in various animal species and to help screen for hypoglycemic drugs. STZ induces …

Chronic hyperglycemia and the corresponding glucotoxicity are the main pathogenic
mechanisms of diabetes and its complications. Streptozotocin (STZ)-induced diabetic animal …

Chronic overnutrition creates chronic hyperglycemia that can gradually induce insulin
resistance and insulin secretion impairment. These disorders, if not intervened, will …

Diabetes is one of the five leading causes of death in the world, with type 2 diabetes
occurring more frequently than type 1. Management of diabetes without side effects is still a …

Diabetes mellitus is a serious disease affecting about 5% of people worldwide. Diabetes is
characterized by hyperglycemia and impairment in insulin secretion and/or action …

The glymphatic system has recently been shown to clear brain extracellular solutes and
abnormalities in glymphatic clearance system may contribute to both initiation and …

Diabetes is the most prevalent disorder in the world characterized by uncontrolled high
blood glucose levels and nephropathy is one of the chief complications allied with …

Streptozotocin (STZ) is currently the most used diabetogenic agent in testing insulin and
new antidiabetic drugs in animals. Due to the toxic and disruptive nature of STZ on organs …