Targeting epigenetic regulators to overcome drug resistance in cancers

N Wang, T Ma, B Yu - Signal transduction and targeted therapy, 2023 - nature.com
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Resveratrol: A double-edged sword in health benefits

B Salehi, AP Mishra, M Nigam, B Sener, M Kilic… - Biomedicines, 2018 - mdpi.com
Resveratrol (3, 5, 4′-trihydroxy-trans-stilbene) belongs to polyphenols' stilbenoids group,
possessing two phenol rings linked to each other by an ethylene bridge. This natural …

The roles of histone deacetylases and their inhibitors in cancer therapy

G Li, Y Tian, WG Zhu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Nutritional implications of ginger: Chemistry, biological activities and signaling pathways

R Kiyama - The Journal of nutritional biochemistry, 2020 - Elsevier
Abstract Ginger (Zingiber officinale Roscoe) has been used as a food, spice, supplement
and flavoring agent and in traditional medicines due to its beneficial characteristics such as …

Beneficial effects of dietary polyphenols on gut microbiota and strategies to improve delivery efficiency

A Kumar Singh, C Cabral, R Kumar, R Ganguly… - Nutrients, 2019 - mdpi.com
The human intestine contains an intricate ecological community of dwelling bacteria,
referred as gut microbiota (GM), which plays a pivotal role in host homeostasis. Multiple …

Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment

W Li, F Li, X Zhang, HK Lin, C Xu - Signal transduction and targeted …, 2021 - nature.com
More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Therapeutic potential of Aloe vera—A miracle gift of nature

R Kumar, AK Singh, A Gupta, A Bishayee, AK Pandey - Phytomedicine, 2019 - Elsevier
Background Aloe vera is commonly used in the primary health care of human beings since
time immemorial. It is an herb widely used in various traditional systems of medicine …

Targeting tumor-associated macrophages as an antitumor strategy

N Cheng, X Bai, Y Shu, O Ahmad, P Shen - Biochemical pharmacology, 2021 - Elsevier
Tumor-associated macrophages (TAMs) are the most widely infiltrating immune cells in the
tumor microenvironment (TME). Clinically, the number of TAMs is closely correlated with …

[图书][B] Recent advancement in white biotechnology through fungi

AN Yadav, S Singh, S Mishra, A Gupta - 2019 - Springer
White biotechnology, or industrial biotechnology, is drawing much attention as a solution to
produce energy, chemicals and other materials from renewable resources. White …

The emerging roles of HDACs and their therapeutic implications in cancer

R Hai, D Yang, F Zheng, W Wang, X Han… - European Journal of …, 2022 - Elsevier
Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …