[HTML][HTML] Endothelial dysfunction in pulmonary hypertension: cause or consequence?
K Kurakula, VFED Smolders, O Tura-Ceide… - Biomedicines, 2021 - mdpi.com
Pulmonary arterial hypertension (PAH) is a rare, complex, and progressive disease that is
characterized by the abnormal remodeling of the pulmonary arteries that leads to right …
characterized by the abnormal remodeling of the pulmonary arteries that leads to right …
[HTML][HTML] Metabolic reprogramming, oxidative stress, and pulmonary hypertension
Mitochondria are highly dynamic organelles essential for cell metabolism, growth, and
function. It is becoming increasingly clear that endothelial cell dysfunction significantly …
function. It is becoming increasingly clear that endothelial cell dysfunction significantly …
[HTML][HTML] BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics
C Hiepen, J Jatzlau, S Hildebrandt, B Kampfrath… - PLoS …, 2019 - journals.plos.org
Balanced transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP)-
signaling is essential for tissue formation and homeostasis. While gain in TGFβ signaling is …
signaling is essential for tissue formation and homeostasis. While gain in TGFβ signaling is …
[HTML][HTML] Pulmonary hypertension secondary to pulmonary fibrosis: clinical data, histopathology and molecular insights
G Ruffenach, J Hong, M Vaillancourt, L Medzikovic… - Respiratory …, 2020 - Springer
Pulmonary hypertension (PH) developing secondarily in pulmonary fibrosis (PF) patients
(PF-PH) is a frequent co-morbidity. The high prevalence of PH in PF patients is very …
(PF-PH) is a frequent co-morbidity. The high prevalence of PH in PF patients is very …
[HTML][HTML] An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension
GRT Ryanto, K Ikeda, K Miyagawa, L Tu… - Nature …, 2021 - nature.com
Pulmonary arterial hypertension is a progressive fatal disease that is characterized by
pathological pulmonary artery remodeling, in which endothelial cell dysfunction is critically …
pathological pulmonary artery remodeling, in which endothelial cell dysfunction is critically …
Novel mechanisms targeted by drug trials in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare disease associated with abnormally
elevated pulmonary pressures and right heart failure resulting in high morbidity and …
elevated pulmonary pressures and right heart failure resulting in high morbidity and …
[HTML][HTML] Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities
R Kumar, Ö Aktay-Cetin, V Craddock… - PLoS …, 2023 - journals.plos.org
The Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) and its sublineages pose a new challenge to healthcare …
Coronavirus 2 (SARS-CoV-2) and its sublineages pose a new challenge to healthcare …
The hallmarks of severe pulmonary arterial hypertension: the cancer hypothesis—ten years later
CD Cool, WM Kuebler, HJ Bogaard… - … of Physiology-Lung …, 2020 - journals.physiology.org
Severe forms of pulmonary arterial hypertension (PAH) are most frequently the
consequence of a lumen-obliterating angiopathy. One pathobiological model is that the …
consequence of a lumen-obliterating angiopathy. One pathobiological model is that the …
Advanced in vitro lung models for drug and toxicity screening: the promising role of induced pluripotent stem cells
The substantial socioeconomic burden of lung diseases, recently highlighted by the
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …
Energy metabolism: A newly emerging target of BMP signaling in bone homeostasis
J Yang, H Ueharu, Y Mishina - Bone, 2020 - Elsevier
Energy metabolism is the process of generating energy (ie ATP) from nutrients. This process
is indispensable for cell homeostasis maintenance and responses to varying conditions …
is indispensable for cell homeostasis maintenance and responses to varying conditions …