The process of ovarian aging: it is not just about oocytes and granulosa cells

A Camaioni, MA Ucci, L Campagnolo… - Journal of assisted …, 2022 - Springer
Ovarian age is classically considered the main cause of female reproductive infertility. In
women, the process proceeds as an ongoing decline in the primordial follicle stockpile and it …

Human endometrial mesenchymal stem cells restore ovarian function through improving the renewal of germline stem cells in a mouse model of premature ovarian …

D Lai, F Wang, X Yao, Q Zhang, X Wu… - Journal of translational …, 2015 - Springer
Background Human endometrial mesenchymal stem cells (EnSCs) derived from menstrual
blood have mesenchymal stem/stromal cells (MSCs) characteristics and can differentiate …

Reproductive issues in patients undergoing hematopoietic stem cell transplantation: an update

M Guida, MA Castaldi, R Rosamilio, V Giudice… - Journal of ovarian …, 2016 - Springer
Abstract In 1963 George Mathé announced to the world that he had cured a patient of
leukaemia by means of a bone-marrow transplant. Since than much progress has been …

hUMSCs regulate the differentiation of ovarian stromal cells via TGF-β1/Smad3 signaling pathway to inhibit ovarian fibrosis to repair ovarian function in POI rats

L Cui, H Bao, Z Liu, X Man, H Liu, Y Hou, Q Luo… - Stem Cell Research & …, 2020 - Springer
Objective The basic pathological changes of primary ovarian insufficiency (POI) include
ovarian tissue fibrosis and follicular development disorders. The human umbilical cord …

Effects of low-intensity pulsed ultrasound (LIPUS)-pretreated human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation on primary ovarian …

L Ling, X Feng, T Wei, Y Wang, Y Wang… - Stem cell research & …, 2017 - Springer
Background Human amnion-derived mesenchymal stem cells (hAD-MSCs) have the
features of mesenchymal stem cells (MSCs). Low-intensity pulsed ultrasound (LIPUS) can …

Resveratrol plays a protective role against premature ovarian failure and prompts female germline stem cell survival

Y Jiang, Z Zhang, L Cha, L Li, D Zhu, Z Fang… - International Journal of …, 2019 - mdpi.com
This study was designed to investigate the protective effect of resveratrol (RES) on
premature ovarian failure (POF) and the proliferation of female germline stem cells (FGSCs) …

Skin-derived mesenchymal stem cells help restore function to ovaries in a premature ovarian failure mouse model

D Lai, F Wang, Z Dong, Q Zhang - PLoS one, 2014 - journals.plos.org
Skin-derived mesenchymal stem cells (SMSCs) can differentiate into the three embryonic
germ layers. For this reason, they are considered a powerful tool for therapeutic cloning and …

Mouse ovarian very small embryonic-like stem cells resist chemotherapy and retain ability to initiate oocyte-specific differentiation

K Sriraman, D Bhartiya, S Anand… - Reproductive …, 2015 - journals.sagepub.com
This study was undertaken to investigate stem cells in adult mouse ovary, the effect of
chemotherapy on them and their potential to differentiate into germ cells. Very small …

Human amniotic epithelial cells inhibit granulosa cell apoptosis induced by chemotherapy and restore the fertility

Q Zhang, M Xu, X Yao, T Li, Q Wang, D Lai - Stem Cell Research & …, 2015 - Springer
Introduction Premature ovarian failure and insufficiency are significant long-term side-effects
of chemotherapy for female cancer patients. Recently, stem cell transplantation has been …

A bioengineered in situ ovary (ISO) supports follicle engraftment and live-births post-chemotherapy

MJ Buckenmeyer, M Sukhwani… - Journal of Tissue …, 2023 - journals.sagepub.com
Female cancer patients who have undergone chemotherapy have an elevated risk of
developing ovarian dysfunction and failure. Experimental approaches to treat iatrogenic …