Pregnancy at advanced maternal age (age> 35 years old) is considered a risk factor for
adverse maternal and perinatal outcomes. Yet, pregnancies of advanced maternal age have …

Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Mitochondria, fundamental organelles in cell metabolism, and ATP synthesis are
responsible for generating reactive oxygen species (ROS), calcium homeostasis, and cell …

Ovarian aging is a natural and physiological aging process characterized by loss of quantity
and quality of oocyte or follicular pool. As it is generally accepted that women are born with a …

The ovary ages earlier than most other tissues, yet the underlying mechanisms remain
elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in …

Advanced maternal age (AMA) is a growing trend world-wide and is traditionally defined as
childbearing in women over 35 years of age. The purpose of our study was to determine the …

Advanced age is a primary risk factor for female infertility due to reduced ovarian reserve
and declining oocyte quality. However, as an important contributing factor, the role of …

In a society where women often want successful careers and equal opportunities to men, the
early nature of ovarian aging often forces women to make difficult life choices between …

Abstract Sirtuin-3 (SIRT3), the main deacetylase in the mitochondria, maintains cellular
energy metabolism and redox balance by deacetylating mitochondrial proteins in a NAD+ …

There is increasing evidence that mitophagy, a specialized form of autophagy to degrade
and clear long-lived or damaged mitochondria, is impaired in aging and age-related …