The immune system and developmental programming of brain and behavior

SD Bilbo, JM Schwarz - Frontiers in neuroendocrinology, 2012 - Elsevier
The brain, endocrine, and immune systems are inextricably linked. Immune molecules have
a powerful impact on neuroendocrine function, including hormone–behavior interactions …

Cytokines and CNS development

BE Deverman, PH Patterson - Neuron, 2009 - cell.com
Cytokines are pleotrophic proteins that coordinate the host response to infection as well as
mediate normal, ongoing signaling between cells of nonimmune tissues, including the …

Individual human cortical progenitors can produce excitatory and inhibitory neurons

RN Delgado, DE Allen, MG Keefe, WR Mancia Leon… - Nature, 2022 - nature.com
The cerebral cortex is a cellularly complex structure comprising a rich diversity of neuronal
and glial cell types. Cortical neurons can be broadly categorized into two classes …

Assembly of functionally integrated human forebrain spheroids

F Birey, J Andersen, CD Makinson, S Islam, W Wei… - Nature, 2017 - nature.com
The development of the nervous system involves a coordinated succession of events
including the migration of GABAergic (γ-aminobutyric-acid-releasing) neurons from ventral …

Fused cerebral organoids model interactions between brain regions

JA Bagley, D Reumann, S Bian, J Lévi-Strauss… - Nature …, 2017 - nature.com
Human brain development involves complex interactions between different regions,
including long-distance neuronal migration or formation of major axonal tracts. Different …

Purification and characterization of human neural stem and progenitor cells

DD Liu, JQ He, R Sinha, AE Eastman, AM Toland… - Cell, 2023 - cell.com
The human brain undergoes rapid development at mid-gestation from a pool of neural stem
and progenitor cells (NSPCs) that give rise to the neurons, oligodendrocytes, and astrocytes …

Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke

Y Werner, E Mass, P Ashok Kumar, T Ulas… - Nature …, 2020 - nature.com
Monocyte-derived and tissue-resident macrophages are ontogenetically distinct
components of the innate immune system. Assessment of their respective functions in …

Human cerebellar organoids with functional Purkinje cells

A Atamian, M Birtele, N Hosseini, T Nguyen, A Seth… - Cell Stem Cell, 2024 - cell.com
Research on human cerebellar development and disease has been hampered by the need
for a human cell-based system that recapitulates the human cerebellum's cellular diversity …

Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex

B Arno, F Grassivaro, C Rossi, A Bergamaschi… - Nature …, 2014 - nature.com
Microglia are observed in the early developing forebrain and contribute to the regulation of
neurogenesis through still unravelled mechanisms. In the developing cerebral cortex …

Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling

E Kokovay, S Goderie, Y Wang, S Lotz, G Lin, Y Sun… - Cell stem cell, 2010 - cell.com
Neural progenitor cells (NPCs) in the adult subventricular zone (SVZ) are associated with
ependymal and vasculature niches, which regulate stem cell self-renewal and …