Since 2000, a good deal of progress has been made in malaria control. However, there is
still an unacceptably high burden of the disease and numerous challenges limiting …

The synthesis and antiplasmodial evaluation of new hybrids combining the pharmacophore
structures of artemisinin, ciprofloxacin or norfloxacin, and 7-chloroquinoline are reported in …

Thia analogs of fosmidomycin are potent inhibitors of the non-mevalonate isoprenoid
biosynthesis enzyme 1-deoxy-d-xylulose 5-phosphate reductoisomerase (IspC, Dxr) of …

Deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) is one of the key enzymes in the
MEP terpenoid biosynthetic pathway. It catalyzes the rate-limiting step of the pathway …

Synthetic pathways have been developed to access a series of N-benzylated
phosphoramidic acid derivatives as novel, achiral analogues of the established Plasmodium …

A virtual screening study with ArgusLab 4.0. 1 was performed on 1-deoxy-D-xylulose-5-
phosphate reductoisomerase (DXR), the second enzyme in the methyl erythritol phosphate …

To overcome antibiotic resistance in pathogenic microorganisms, research work is being
directed towards finding alternative targets in bacteria towards which novel antibiotics can …

Ich versichere an Eides Statt, dass die Dissertation von mir selbständig und ohne
unzulässige fremde Hilfe unter Beachtung der „Grundsätze zur Sicherung guter …