Relaxin family peptides and their receptors

RAD Bathgate, ML Halls… - Physiological …, 2013 - journals.physiology.org
There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous …

Relaxin—a pleiotropic hormone and its emerging role for experimental and clinical therapeutics

T Dschietzig, C Bartsch, G Baumann… - Pharmacology & …, 2006 - Elsevier
The insulin-related peptide hormone relaxin (Rlx) is known as pregnancy hormone for
decades. In the 1980s, researchers began to recognize the highly intriguing fact that Rlx …

[HTML][HTML] N-carbamylglutamate and L-arginine improved maternal and placental development in underfed ewes

H Zhang, L Sun, Z Wang, M Deng, H Nie… - …, 2016 - rep.bioscientifica.com
The objectives of this study were to determine how dietary supplementation of N-
carbamylglutamate (NCG) and rumen-protected L-arginine (RP-Arg) in nutrient-restricted …

Alternative splicing of G protein-coupled receptors: physiology and pathophysiology

D Markovic, RAJ Challiss - Cellular and molecular life sciences, 2009 - Springer
The G protein-coupled receptors (GPCRs) are a superfamily of transmembrane receptors
that have a broad distribution and can collectively recognise a diverse array of ligands …

The role of relaxin in normal and abnormal uterine function during the menstrual cycle and early pregnancy

SA Marshall, SN Senadheera, LJ Parry… - Reproductive …, 2017 - journals.sagepub.com
The hormone relaxin is a 6-kDa peptide with high structural similarity to insulin. It is primarily
produced by the corpus luteum during pregnancy but is also synthesized by other …

Evidence for local relaxin ligand‐receptor expression and function in arteries

J Novak, LJ Parry, JE Matthews, LJ Kerchner… - The FASEB …, 2006 - Wiley Online Library
Relaxin is a 6 kDa protein hormone produced by the corpus luteum and secreted into the
blood during pregnancy in rodents and humans. Growing evidence indicates that circulating …

[HTML][HTML] INSL3 in the ruminant: a powerful indicator of gender-and genetic-specific feto-maternal dialogue

R Anand-Ivell, S Hiendleder, C Viñoles, GB Martin… - PloS one, 2011 - journals.plos.org
The hormone Insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells
from both fetal and adult testes. Consequently, it is a major gender-specific circulating …

[HTML][HTML] mRNA and Protein Expression in Human Fetal Membrane Cells: Potential Biomarkers for Preterm Prelabor Rupture of the Fetal Membranes?

E Mikkelsen, B Huppertz, R Singh, K Ravn… - International journal of …, 2023 - mdpi.com
Clinically, unique markers in fetal membrane cells may contribute to the search for
biomarkers for preterm prelabor rupture of the fetal membranes (pPROM) in maternal blood …

Relaxin stimulates osteoclast differentiation and activation

A Ferlin, A Pepe, A Facciolli, L Gianesello, C Foresta - Bone, 2010 - Elsevier
Relaxin is a pleiotropic hormone with actions in reproductive and non-reproductive tissues,
and has a role in tumor biology. It can promote growth, differentiation and invasiveness of …

[HTML][HTML] Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat

M Filonzi, LC Cardoso, MT Pimenta… - Reproductive biology …, 2007 - Springer
Background Relaxin is the endogenous ligand of the G-protein coupled receptor RXFP1,
previously known as LGR7. In humans relaxin can also activate, but with lower affinity, the …