Gut-liver axis: Pathophysiological concepts and clinical implications

H Tilg, TE Adolph, M Trauner - Cell metabolism, 2022 - cell.com
Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …

Short-chain fatty-acid-producing bacteria: key components of the human gut microbiota

W Fusco, MB Lorenzo, M Cintoni, S Porcari… - Nutrients, 2023 - mdpi.com
Short-chain fatty acids (SCFAs) play a key role in health and disease, as they regulate gut
homeostasis and their deficiency is involved in the pathogenesis of several disorders …

Short-chain fatty acids in diseases

D Zhang, YP Jian, YN Zhang, Y Li, LT Gu… - Cell Communication and …, 2023 - Springer
Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation
of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate …

[HTML][HTML] Functions of gut microbiota metabolites, current status and future perspectives

J Liu, Y Tan, H Cheng, D Zhang, W Feng… - Aging and …, 2022 - ncbi.nlm.nih.gov
Gut microbiota, a collection of microorganisms that live within gastrointestinal tract, provides
crucial signaling metabolites for the physiological of hosts. In healthy state, gut microbiota …

Dietary fiber‐derived short‐chain fatty acids: A potential therapeutic target to alleviate obesity‐related nonalcoholic fatty liver disease

S Zhang, J Zhao, F Xie, H He, LJ Johnston… - Obesity …, 2021 - Wiley Online Library
Over the past several decades, increasing global prevalence of obesity‐related
nonalcoholic fatty liver disease (NAFLD) has been one of main challenges to human health …

Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections

LM Ney, M Wipplinger, M Grossmann… - Open …, 2023 - royalsocietypublishing.org
The human intestinal microbiome substantially affects human health and resistance to
infections in its dynamic composition and varying release of microbial-derived metabolites …

Host-microbiome interactions: Gut-Liver axis and its connection with other organs

S Anand, SS Mande - npj Biofilms and Microbiomes, 2022 - nature.com
An understanding of connections between gut microbiome and liver has provided important
insights into the pathophysiology of liver diseases. Since gut microbial dysbiosis increases …

The role of gut–liver axis in gut microbiome dysbiosis associated NAFLD and NAFLD-HCC

Q Song, X Zhang - Biomedicines, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is considered as one of the most prevalent chronic
liver diseases worldwide due to the rapidly rising prevalence of obesity and metabolic …

Inflammatory and fibrotic mechanisms in NAFLD—Implications for new treatment strategies

YA Lee, SL Friedman - Journal of Internal Medicine, 2022 - Wiley Online Library
Non‐alcoholic fatty liver disease is comprised of either simple steatosis (non‐alcoholic fatty
liver) or a more advanced inflammatory and fibrogenic stage (non‐alcoholic steatohepatitis …

Short-chain fatty acid: An updated review on signaling, metabolism, and therapeutic effects

K Rekha, B Venkidasamy, R Samynathan… - Critical Reviews in …, 2024 - Taylor & Francis
Fatty acids are good energy sources (9 kcal per gram) that aerobic tissues can use except
for the brain (glucose is an alternative source). Apart from the energy source, fatty acids are …