Searching for effective and selective anti‐inflammatory agents, our study involved designing
and synthesizing new pyrazole and pyrazolo [1, 5‐a] pyrimidine derivatives 4–11. The …

Oral antioxidant nanozymes bring great promise for inflammatory bowel disease (IBD)
treatment. To efficiently eliminate reactive oxygen species (ROS), various metal‐based …

Cancer and inflammation interlink with many pathways. Millions of people died because of
these two disorders. Major pathways that cause both inflammation and cancer are STAT3 …

The inflammatory response is a major pathological feature in most kidney diseases and
often evokes compensatory mechanisms. Recent evidence suggests that TSG-6 (tumor …

Given the close association between inflammation and cancer, combining anti-inflammation
therapy is prominent to improve the anticancer effect. Based on I-1, a series of agents …

Searching for new compounds with anti-inflammatory properties is a significant target since
inflammation is a major cause of pain. A series of pyrazole, imidazopyrazolone, and …

The inflammatory response plays an important role in neuroprotection and regeneration
after ischemic insult. The use of non-steroidal anti-inflammatory drugs has been a matter of …

Hyperinflammation can lead to tissue injury, organ failure, and even fatalities by
overproducing proinflammatory cytokines. The long-term safety and outstanding anti …

The NLRP3 inflammasome's core and most specific protein, NLRP3, has a variety of
functions in inflammation-driven diseases. Costunolide (COS) is the major active ingredient …

Curcumin has been modified in various ways to broaden its application in medicine and
address its limitations. In this study, we present a series of curcumin-based derivatives …