Development and in vitro effects of thiolated chitosan nanoparticles for the sustained delivery of inflammation suppressing bioactive peptide

A Balde, S Benjakul, SK Kim, RA Nazeer - Journal of Drug Delivery Science …, 2023 - Elsevier
Marine food derived compounds are highly studied as therapeutics due to their biological
activity. Moreover, due to high mucoadhesivity and solubility, chitosan (CS) is widely used …

TSG-6 (Tumor Necrosis Factor-α-Stimulated Gene/Protein-6): an emerging remedy for renal inflammation

Y Jiang, LM Glasstetter, A Lerman, LO Lerman - Hypertension, 2023 - Am Heart Assoc
The inflammatory response is a major pathological feature in most kidney diseases and
often evokes compensatory mechanisms. Recent evidence suggests that TSG-6 (tumor …

[HTML][HTML] Carrier-free curcumin nanoassemblies for enhancing therapy effects in inflammation related disease

L Zhang, H Xia, S Du, N Zhao, X Zhang, Q Pan, S Xu… - Materials & Design, 2022 - Elsevier
Hyperinflammation can lead to tissue injury, organ failure, and even fatalities by
overproducing proinflammatory cytokines. The long-term safety and outstanding anti …

[HTML][HTML] Synthesis of tetracyclic spirooxindolepyrrolidine-engrafted hydantoin scaffolds: crystallographic analysis, molecular docking studies and evaluation of their …

A Toumi, FIA Abdella, S Boudriga, TYA Alanazi… - Molecules, 2023 - mdpi.com
In a sustained search for novel potential drug candidates with multispectrum therapeutic
application, a series of novel spirooxindoles was designed and synthesized via …

[HTML][HTML] Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatments

IF Ugidos, P González-Rodríguez… - Neural Regeneration …, 2023 - journals.lww.com
The inflammatory response plays an important role in neuroprotection and regeneration
after ischemic insult. The use of non-steroidal anti-inflammatory drugs has been a matter of …

[PDF][PDF] Tectochrysin Attenuates Cisplatin-induced Hepatotoxicity by Restoring Biochemical, Inflammatory and Histological Profile in Rats.

MU Ijaz, Z Rafi, A Hamza, M Tariq… - Pakistan Veterinary …, 2023 - researchgate.net
Cisplatin is an efficacious anticancerous chemotherapeutic agent that is used to cure
multiple types of malignancies. However, it has several hazardous effects on multiple …

[HTML][HTML] Targeted therapy for head and neck squamous cell carcinoma microenvironment

Z Guo, K Li, P Liu, X Zhang, J Lv, X Zeng… - Frontiers in …, 2023 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) originates from the squamous
epithelium of the oral cavity, oropharynx, larynx, and hypopharynx. HNSCC in the oral cavity …

Synthesis and biological evaluation of resveratrol amide derivatives as selective COX-2 inhibitors

M Xin, H Wu, Y Du, S Liu, F Zhao, X Mou - Chemico-Biological Interactions, 2023 - Elsevier
Selective COX-2 inhibitors have been considered to be reliable alternatives to tNSAIDs, but
most of them were withdrawn from the market due to their risk of heart attack and stroke …

[HTML][HTML] Unravelling the gastroprotective potential of Kefir: exploring antioxidant effects in preventing gastric ulcers

LZ Côco, R Aires, GR Carvalho, ES Belisário, MKK Yap… - Cells, 2023 - mdpi.com
The present study was conducted to evaluate the protective effect of milk kefir against NSAID-
induced gastric ulcers. Male Swiss mice were divided into three groups: control (Vehicle; …

Tailored quinoline hybrids as promising COX-2/15-LOX dual inhibitors endowed with diverse safety profile: Design, synthesis, SAR, and histopathological study

ME Hegazy, ES Taher, AH Ghiaty, AH Bayoumi - Bioorganic Chemistry, 2024 - Elsevier
Complications of the worldwide use of non-steroidal anti-inflammatory drugs (NSAIDs)
sparked scientists to design novel harmless alternatives as an urgent need. So, a unique …