Computational and statistical analysis of metabolomics data

S Ren, AA Hinzman, EL Kang, RD Szczesniak, LJ Lu - Metabolomics, 2015 - Springer
Metabolomics is the comprehensive study of small molecule metabolites in biological
systems. By assaying and analyzing thousands of metabolites in biological samples, it …

[HTML][HTML] Multi-omics and metabolic modelling pipelines: challenges and tools for systems microbiology

M Fondi, P Liò - Microbiological research, 2015 - Elsevier
Integrated-omics approaches are quickly spreading across microbiology research labs,
leading to (i) the possibility of detecting previously hidden features of microbial cells like …

Integrated omics analysis of specialized metabolism in medicinal plants

A Rai, K Saito, M Yamazaki - The Plant Journal, 2017 - Wiley Online Library
Medicinal plants are a rich source of highly diverse specialized metabolites with important
pharmacological properties. Until recently, plant biologists were limited in their ability to …

Genomics of lactic acid bacteria: Current status and potential applications

C Wu, J Huang, R Zhou - Critical Reviews in Microbiology, 2017 - Taylor & Francis
Lactic acid bacteria (LAB) are widely used for the production of a variety of foods and feed
raw materials where they contribute to flavor and texture of the fermented products. In …

[HTML][HTML] Metabolomics and modelling approaches for systems metabolic engineering

JK Khanijou, H Kulyk, C Bergès, LW Khoo, P Ng… - Metabolic Engineering …, 2022 - Elsevier
Metabolic engineering involves the manipulation of microbes to produce desirable
compounds through genetic engineering or synthetic biology approaches. Metabolomics …

Influence of HEK293 metabolism on the production of viral vectors and vaccine

E Petiot, M Cuperlovic-Culf, CF Shen, A Kamen - Vaccine, 2015 - Elsevier
Mammalian cell cultures are increasingly used for the production of complex
biopharmaceuticals including viral vectors and vaccines. HEK293 is the predominant cell …

Green genes: bioinformatics and systems-biology innovations drive algal biotechnology

MJMF Reijnders, RGA van Heck, CMC Lam… - Trends in …, 2014 - cell.com
Many species of microalgae produce hydrocarbons, polysaccharides, and other valuable
products in significant amounts. However, large-scale production of algal products is not yet …

Plant metabolic modeling: achieving new insight into metabolism and metabolic engineering

K Baghalian, MR Hajirezaei, F Schreiber - The Plant Cell, 2014 - academic.oup.com
Abstract Models are used to represent aspects of the real world for specific purposes, and
mathematical models have opened up new approaches in studying the behavior and …

[HTML][HTML] A genome-scale metabolic flux model of Escherichia coli K–12 derived from the EcoCyc database

DS Weaver, IM Keseler, A Mackie, IT Paulsen… - BMC systems …, 2014 - Springer
Background Constraint-based models of Escherichia coli metabolic flux have played a key
role in computational studies of cellular metabolism at the genome scale. We sought to …

[HTML][HTML] A genome-scale metabolic model of potato late blight suggests a photosynthesis suppression mechanism

K Botero, S Restrepo, A Pinzón - BMC genomics, 2018 - Springer
Background Phytophthora infestans is a plant pathogen that causes an important plant
disease known as late blight in potato plants (Solanum tuberosum) and several other …