Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

The emphasis on mechanisms driving multiple sclerosis (MS) symptomatic worsening
suggests that we move beyond categorical clinical classifiers such as relapsing–remitting …

Importance There is a lack of validated biomarkers for disability progression independent of
relapse activity (PIRA) in multiple sclerosis (MS). Objective To determine how serum glial …

Anti-CD20 therapy to deplete B cells is highly efficacious in preventing new white matter
lesions in patients with relapsing-remitting multiple sclerosis (RRMS), but its protective …

Modern management of MS targets No Evidence of Disease Activity (NEDA): no clinical
relapses, no magnetic resonance imaging (MRI) disease activity and no disability …

Importance Emerging evidence suggests that progression independent of relapse activity
(PIRA) is a substantial contributor to long-term disability accumulation in relapsing-remitting …

Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system
(CNS), characterized by demyelination and neurodegeneration. Oligodendrocytes play a …

In this paper we describe and validate a longitudinal method for whole-brain segmentation
of longitudinal MRI scans. It builds upon an existing whole-brain segmentation method that …

People with multiple sclerosis (MS) have traditionally been classified has having relapsing-
remitting (RR) or progressive (either secondary or primary progressive) MS based on (1) the …

Background and Objectives Progression independent of relapse activity (PIRA) is a crucial
determinant of overall disability accumulation in multiple sclerosis (MS). Accelerated brain …