In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

DNA methylation plays a critical role during development, particularly in repressing
retrotransposons. The mammalian methylation landscape is dependent on the combined …

Background Cytosine DNA methylation is widely described as a transcriptional repressive
mark with the capacity to silence promoters. Epigenome engineering techniques enable …

DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …

DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …

DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two
important heterochromatin-enriched marks that frequently cooperate in silencing repetitive …

Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …

Hypoxia is the major influence factor in physiological and pathological courses which are
mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions …

New Findings What is the topic of this review? This review outlines the history of research on
epigenetic adaptations to heat exposure. The perspective taken is that adaptations reflect …