Abstract Calcium (Ca 2+) is one of the most universal secondary messengers, owing its
success to the immense concentration gradient across the plasma membrane …

Capsaicin, a major ingredient in chili pepper, has broad pharmaceutical applications,
including relieving pain, anti-inflammation, and treating psoriasis. In dermatological biology …

Capsaicin, a compound found in chili peppers, causes burning sensations by acting on the
peripheral sensory system. However, it has also been reported to exert substantial effects on …

Abstract Lazertinib (JNJ-73841937, YH25448) is a mutant-selective irreversible epidermal
growth factor receptor tyrosine kinase inhibitor targeting both the T790M and activating …

Nav1. 7 is closely associated with neuropathic pain. Hydrogen sulfide (H2S) has recently
been reported to be involved in numerous biological functions, and it has been shown that …

Abstract Huntingtin-associated protein 1 (HAP1) is a polyglutamine (polyQ) length-
dependent interactor with causal agents in several neurodegenerative diseases and has …

The activation of α2 adrenergic receptors contributes to analgesia not only in the central
nervous system but also in the peripheral nervous system. We reported that noradrenaline …

Transient receptor potential (TRP) channels are activated by various extracellular and
intracellular stimuli and are involved in many physiological events. Because compounds that …

Dorsal root ganglia (DRG) neurons transduce and convey somatosensory information from
the periphery to the central nervous system. Adrenergic mediators are known to modulate …

Transient receptor potential vanilloid 1 (TRPV1) is a voltage-dependent non-selective cation
channel activated by capsaicin, the main pungent ingredient of chili peppers, and noxious …