Relevance of human papillomaviruses in head and neck cancer—what remains in 2021 from a clinician's point of view?

M Hoffmann, ES Quabius - Viruses, 2021 - mdpi.com
Human papillomaviruses (HPV) cause a subset of head and neck cancers (HNSCC). HPV16
predominantly signs responsible for approximately 10% of all HNSCC and over 50% of …

[HTML][HTML] Classification of vulvar squamous cell carcinoma and precursor lesions by p16 and p53 immunohistochemistry: considerations, caveats, and an algorithmic …

H Yang, N Almadani, EF Thompson, B Tessier-Cloutier… - Modern Pathology, 2023 - Elsevier
There is emerging evidence that vulvar squamous cell carcinoma (VSCC) can be
prognostically subclassified into 3 groups based on human papillomavirus (HPV) and p53 …

Low Prevalence of HPV Related Oropharyngeal Carcinogenesis in Northern Sardinia

F Bussu, N Muresu, C Crescio, R Gallus, D Rizzo… - Cancers, 2022 - mdpi.com
Simple Summary Oropharyngeal squamous cell carcinomas (OPSCCs) are the only head
and neck malignancy with a clear increase in prevalence in Western countries, due to the …

Utilization of p53 and p16 Immunohistochemistry in the Classification of Human Papillomavirus–Associated, p53 Wild-Type, and p53 Abnormal Oral Epithelial …

R Novack, E Chapman, J Gao, B Horst, LN Hoang… - Modern Pathology, 2023 - Elsevier
Abstract p53 immunohistochemistry (IHC) has recently been shown to be a clinically useful
marker for predicting risk of progression to invasive squamous cell carcinoma in oral …

PD-L1 immunohistochemical expression considering HPV status in oropharyngeal squamous cell carcinoma

RS ANJOS, MV CARVALHO, RTF Costa… - Brazilian Oral …, 2024 - SciELO Brasil
This systematic review aims to determine whether the presence of human papillomavirus
(HPV) influences the immunohistochemical expression of programmed cell death-1 ligand …

The role of the p16 and p53 tumor suppressor proteins and viral HPV16 E6 and E7 oncoproteins in the Assessment of Survival in patients with Head and Neck …

A Lifsics, M Cistjakovs, L Sokolovska, R Deksnis… - Cancers, 2023 - mdpi.com
Simple Summary The role of human papillomavirus (HPV) in the survival of patients with
head and neck squamous cell carcinoma (HNSCC) is an important topic. The recognition of …

Accuracy of p16 IHC in classifying HPV-driven OPSCC in different populations

R Gallus, IH Nauta, L Marklund, D Rizzo, C Crescio… - Cancers, 2023 - mdpi.com
Simple Summary p16 IHC is the HPV detection method suggested by the current version of
the TNM (AJCC 8th edition) for oropharyngeal squamocellular carcinoma. However, its …

Genetic Mutations Associated with Inflammatory Response Caused by HPV Integration in Oropharyngeal Squamous Cell Carcinoma

M Atique, I Muniz, F Farshadi, M Hier, A Mlynarek… - Biomedicines, 2023 - mdpi.com
(1) Background: Head and neck cancer (HNC) ranks as the sixth most prevalent cancer in
the world. In addition to the traditional risk factors such as alcohol and tobacco consumption …

[HTML][HTML] p16 and p53 can Serve as Prognostic Markers for Head and Neck Squamous Cell Carcinoma

Y Wang, F Wang, S Wang, L Zhang, H Fu, L Sun… - International Dental …, 2024 - Elsevier
Objective The present study aimed to explore the expression and clinical significance of
human papilloma virus-related pathogenic factors (p16, cyclin D1, p53) in patients with head …

Abnormal p53 Immunohistochemical Patterns Are Associated with Regional Lymph Node Metastasis in Oral Cavity Squamous Cell Carcinoma at Time of Surgery

TYY Lin, KYP Liu, R Novack, PS Mattu, TL Ng… - Modern Pathology, 2024 - Elsevier
Introduction Sixty to eighty percent of oral cavity invasive squamous cell carcinoma (OSCC)
demonstrate molecular alterations in TP53. The presence of TP53 mutations in multiple …