Mitochondrial dysfunction: roles in skeletal muscle atrophy

X Chen, Y Ji, R Liu, X Zhu, K Wang, X Yang… - Journal of Translational …, 2023 - Springer
Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Physiological and environmental factors affecting cancer risk and prognosis in obesity

PFS Etet, L Vecchio, AHN Kamdje, PN Mimche… - Seminars in Cancer …, 2023 - Elsevier
Obesity results from a chronic excessive accumulation of adipose tissue due to a long-term
imbalance between energy intake and expenditure. Available epidemiological and clinical …

Ketogenic diets in pancreatic cancer and associated cachexia: cellular mechanisms and clinical perspectives

NE Cortez, GG Mackenzie - Nutrients, 2021 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and extremely therapy-resistant
cancer. It is estimated that up to 80% of PDAC patients present with cachexia, a multifactorial …

Malnutrition, sarcopenia, and cancer cachexia in gynecologic cancer

M Morton, J Patterson, J Sciuva, J Perni, F Backes… - Gynecologic …, 2023 - Elsevier
Patients with gynecologic cancers are at risk for malnutrition, cancer cachexia, and
sarcopenia. Accumulating data supports that malnourished patients with gynecologic cancer …

Molecular mechanisms and current treatment options for cancer cachexia

SS Ahmad, K Ahmad, S Shaikh, HJ You, EY Lee, S Ali… - Cancers, 2022 - mdpi.com
Simple Summary The primary characteristics of cancer cachexia are weakness, weight loss,
atrophy, fat reduction, and systemic inflammation. Cachexia is strongly associated with …

Targeting cancer cachexia: Molecular mechanisms and clinical study

YF Wang, ZY An, DH Lin, WL Jin - MedComm, 2022 - Wiley Online Library
Cancer cachexia is a complex systemic catabolism syndrome characterized by muscle
wasting. It affects multiple distant organs and their crosstalk with cancer constitute cancer …

Psoas muscle index as a predictor of perioperative outcomes in geriatric patients undergoing spine surgery

MN Pernik, WH Hicks, OS Akbik… - Global Spine …, 2023 - journals.sagepub.com
Study Design Single-center retrospective study. Objective The objective of this study was to
evaluate the association of psoas muscle mass defined sarcopenia with perioperative …

[HTML][HTML] Molecular mechanisms of cancer cachexia. Role of exercise training

E Tamayo-Torres, A Garrido, R de Cabo… - Molecular Aspects of …, 2024 - Elsevier
Cancer-associated cachexia represents a multifactorial syndrome mainly characterized by
muscle mass loss, which causes both a decrease in quality of life and anti-cancer therapy …

Targeting Epigenetic Regulators with HDAC and BET Inhibitors to Modulate Muscle Wasting

L Nevi, N Pöllänen, F Penna, G Caretti - International Journal of …, 2023 - mdpi.com
Epigenetic changes contribute to the profound alteration in the transcriptional program
associated with the onset and progression of muscle wasting in several pathological …

The incidence and management of cancer-related anorexia during treatment with vascular endothelial growth factor receptor-tyrosine kinase inhibitors

S Takahashi, K Matsumoto, K Ohba… - Cancer Management …, 2023 - Taylor & Francis
Cancer-related anorexia is a common complication and frequently occurs in cancer patients
treated with vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR …