Biosynthesis and synthetic biology of psychoactive natural products

CS Jamieson, J Misa, Y Tang… - Chemical Society Reviews, 2021 - pubs.rsc.org
Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …

Hairy root culture: a potent method for improved secondary metabolite production of Solanaceous plants

D Biswas, A Chakraborty, S Mukherjee… - Frontiers in Plant …, 2023 - frontiersin.org
Secondary metabolites synthesized by the Solanaceous plants are of major therapeutic and
pharmaceutical importance, many of which are commonly obtained from the roots of these …

[HTML][HTML] Phytotherapeutic applications of alkaloids in treating breast cancer

S Rampogu, T Balasubramaniyam, JH Lee - Biomedicine & …, 2022 - Elsevier
Breast cancer is one of the major causes of mortality in women worldwide. The current
treatments available are radiation therapy (RT), surgery, endocrine (hormone) therapy (ET) …

Application of molecular imprinting polymers in separation of active compounds from plants

L Zhang, H Yu, H Chen, Y Huang, I Bakunina… - Fitoterapia, 2023 - Elsevier
Molecular imprinting technique is becoming an appealing and prominent strategy to
synthesize materials for target recognition and rapid separation. In recent years, it has been …

An organophotocatalytic late-stage N–CH 3 oxidation of trialkylamines to N-formamides with O 2 in continuous flow

MJP Mandigma, J Žurauskas, CI MacGregor… - Chemical …, 2022 - pubs.rsc.org
We report an organophotocatalytic, N–CH3-selective oxidation of trialkylamines in
continuous flow. Based on the 9, 10-dicyanoanthracene (DCA) core, a new catalyst (DCAS) …

Scopolamine, a toxin-induced experimental model, used for research in Alzheimer's disease

WN Chen, KY Yeong - … (Formerly Current Drug Targets-CNS & …, 2020 - ingentaconnect.com
Scopolamine as a drug is often used to treat motion sickness. Derivatives of scopolamine
have also found applications as antispasmodic drugs among others. In neuroscience …

Functional genomics analysis reveals two novel genes required for littorine biosynthesis

F Qiu, J Zeng, J Wang, JP Huang, W Zhou… - New …, 2020 - Wiley Online Library
Some medicinal plants of the Solanaceae produce pharmaceutical tropane alkaloids (TAs),
such as hyoscyamine and scopolamine. Littorine is a key biosynthetic intermediate in the …

A chromosome-level genome assembly of anesthetic drug–producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane …

W Zhou, C Wang, X Hao, F Chen, Q Huang, T Liu… - Plant …, 2024 - cell.com
Tropane alkaloids (TAs), which are anticholinergic agents, are an essential class of natural
compounds, and there is a growing demand for TAs with anesthetic, analgesic, and …

Aqueous amine-tolerant [2+ 2] photocycloadditions of unactivated olefins

CMF Mansson, NZ Burns - Journal of the American Chemical …, 2022 - ACS Publications
The Kochi–Salomon reaction is the only photochemical [2+ 2] cycloaddition capable of
combining two electronically unactivated olefins into a cyclobutane. Yet, the reaction has …

Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders

R Juza, K Musilek, E Mezeiova… - Medicinal Research …, 2023 - Wiley Online Library
Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …