Biosynthesis and synthetic biology of psychoactive natural products
Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …
structural complexity displayed by such molecules confers diverse biological activities of …
Hairy root culture: a potent method for improved secondary metabolite production of Solanaceous plants
D Biswas, A Chakraborty, S Mukherjee… - Frontiers in Plant …, 2023 - frontiersin.org
Secondary metabolites synthesized by the Solanaceous plants are of major therapeutic and
pharmaceutical importance, many of which are commonly obtained from the roots of these …
pharmaceutical importance, many of which are commonly obtained from the roots of these …
[HTML][HTML] Phytotherapeutic applications of alkaloids in treating breast cancer
S Rampogu, T Balasubramaniyam, JH Lee - Biomedicine & …, 2022 - Elsevier
Breast cancer is one of the major causes of mortality in women worldwide. The current
treatments available are radiation therapy (RT), surgery, endocrine (hormone) therapy (ET) …
treatments available are radiation therapy (RT), surgery, endocrine (hormone) therapy (ET) …
Application of molecular imprinting polymers in separation of active compounds from plants
L Zhang, H Yu, H Chen, Y Huang, I Bakunina… - Fitoterapia, 2023 - Elsevier
Molecular imprinting technique is becoming an appealing and prominent strategy to
synthesize materials for target recognition and rapid separation. In recent years, it has been …
synthesize materials for target recognition and rapid separation. In recent years, it has been …
An organophotocatalytic late-stage N–CH 3 oxidation of trialkylamines to N-formamides with O 2 in continuous flow
MJP Mandigma, J Žurauskas, CI MacGregor… - Chemical …, 2022 - pubs.rsc.org
We report an organophotocatalytic, N–CH3-selective oxidation of trialkylamines in
continuous flow. Based on the 9, 10-dicyanoanthracene (DCA) core, a new catalyst (DCAS) …
continuous flow. Based on the 9, 10-dicyanoanthracene (DCA) core, a new catalyst (DCAS) …
Scopolamine, a toxin-induced experimental model, used for research in Alzheimer's disease
WN Chen, KY Yeong - … (Formerly Current Drug Targets-CNS & …, 2020 - ingentaconnect.com
Scopolamine as a drug is often used to treat motion sickness. Derivatives of scopolamine
have also found applications as antispasmodic drugs among others. In neuroscience …
have also found applications as antispasmodic drugs among others. In neuroscience …
Functional genomics analysis reveals two novel genes required for littorine biosynthesis
F Qiu, J Zeng, J Wang, JP Huang, W Zhou… - New …, 2020 - Wiley Online Library
Some medicinal plants of the Solanaceae produce pharmaceutical tropane alkaloids (TAs),
such as hyoscyamine and scopolamine. Littorine is a key biosynthetic intermediate in the …
such as hyoscyamine and scopolamine. Littorine is a key biosynthetic intermediate in the …
A chromosome-level genome assembly of anesthetic drug–producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane …
Tropane alkaloids (TAs), which are anticholinergic agents, are an essential class of natural
compounds, and there is a growing demand for TAs with anesthetic, analgesic, and …
compounds, and there is a growing demand for TAs with anesthetic, analgesic, and …
Aqueous amine-tolerant [2+ 2] photocycloadditions of unactivated olefins
CMF Mansson, NZ Burns - Journal of the American Chemical …, 2022 - ACS Publications
The Kochi–Salomon reaction is the only photochemical [2+ 2] cycloaddition capable of
combining two electronically unactivated olefins into a cyclobutane. Yet, the reaction has …
combining two electronically unactivated olefins into a cyclobutane. Yet, the reaction has …
Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders
R Juza, K Musilek, E Mezeiova… - Medicinal Research …, 2023 - Wiley Online Library
Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …