Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice

M Corsetti, S Forestier… - Neurogastroenterology & …, 2023 - Wiley Online Library
Background Hyoscine butylbromide (HBB) has been available for use as an antispasmodic
since 1951 and is indicated for the treatment of abdominal pain associated with cramps. A …

New Insight into the pharmacological importance of atropine as the potential inhibitor of AKR1B1 via detailed computational investigations: DFTs, ADMET, molecular …

SA Ejaz, M Aziz, A Ahmed, SS Alotaibi… - Applied Biochemistry …, 2023 - Springer
The aim of this research is to investigate the quantum geometric properties and chemical
reactivity of atropine, a pharmaceutically active tropane alkaloid. Using density functional …

Evaluation of tropane alkaloids in teas and herbal infusions: effect of brewing time and temperature on atropine and scopolamine content

L González-Gómez, S Morante-Zarcero, JAM Pereira… - Toxins, 2023 - mdpi.com
Atropine and scopolamine belong to the tropane alkaloid (TA) family of natural toxins. They
can contaminate teas and herbal teas and appear in infusions. Therefore, this study focused …

Engineering the production of medicinal tropane alkaloids through enhancement of tropinone and littorine biosynthesis in root cultures of Atropa belladonna

J Zeng, M Liu, L Zeng, C Yang, P He, M Lin… - Industrial Crops and …, 2022 - Elsevier
Hyoscyamine and scopolamine are two pharmaceutical tropane alkaloids (TAs) whose
biosynthesis is dependent on tropinone and littorine. The biosynthesis process of tropinone …

Alteration in the callogenesis, tropane alkaloid formation, and gene expression in Hyoscyamus niger under clinorotation

S Pourhabibian, A Iranbakhsh, M Ebadi, H Hassanpour… - Protoplasma, 2024 - Springer
This study aimed to investigate the effects of clinorotation induced by 2-D clinostat on the
growth, tropane alkaloid production, gene expression, antioxidant capacity, and cellular …

Site-Selective Palladium(II)-Catalyzed Methylene C(sp3)–H Diarylation of a Tropane Scaffold

M Zayene, F Le Bideau, P Retailleau… - The Journal of …, 2022 - ACS Publications
A series of 2, 4-di-arylated tropane derivatives was synthesized through a site-selective
palladium-catalyzed β-C (sp3)–H di-arylation process. This type of structure has been …

Effects of Different Planting Densities and Harvesting Periods on the Growth and Major Alkaloids of Anisodus tanguticus (Maxim.) Pascher on the Qinghai–Tibetan …

N Liu, C Chen, B Wang, K Chen, S Feng, D Zhang… - Agriculture, 2022 - mdpi.com
Anisodus tanguticus (Maxim.) Pascher, a medicinal plant growing in the Tibetan Plateau
region with various medicinal values, is mainly used for the extraction of tropane alkaloids …

Analytical and in silico study of the inclusion complexes between tropane alkaloids atropine and scopolamine with cyclodextrins

M Butnariu, M Peana, I Sarac, S Chirumbolo… - Chemical Papers, 2021 - Springer
Datura stramonium L.(Solanaceae) possesses a rich tropane alkaloids (TAs) spectrum. The
plant contains, in particular, the allelopathic compounds scopolamine and atropine, which …

Datura genome reveals duplications of psychoactive alkaloid biosynthetic genes and high mutation rate following tissue culture

A Rajewski, D Carter-House, J Stajich, A Litt - BMC genomics, 2021 - Springer
Abstract Background Datura stramonium (Jimsonweed) is a medicinally and
pharmaceutically important plant in the nightshade family (Solanaceae) known for its …

[HTML][HTML] Interpol review of controlled substances 2016–2019

NS Jones, JH Comparin - Forensic science international: synergy, 2020 - Elsevier
This review paper covers the forensic-relevant literature in controlled substances from 2016
to 2019 as a part of the 19th Interpol International Forensic Science Managers Symposium …