Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of
diabetes. Symptoms of DPN mainly include spontaneous intractable pain that is diffuse and …

In the central nervous system, nitric oxide (NO), a free gas with multitudinous bioactivities, is
mainly produced from the oxidation of L-arginine by neuronal nitric oxide synthase (nNOS) …

Overactivation of N-methyl-D-aspartate receptor (NMDAR) in the spinal cord dorsal horn
(SDH) in the setting of injury represents a key mechanism of neuropathic pain. However …

Neurological and neuropsychiatric disorders are one of the leading causes of disability
worldwide and affect the health of billions of people. Nitric oxide (NO), a free gas with …

Metastatic bone pain and chemotherapy-induced peripheral neuropathic pain are the most
common clinical symptoms in cancer patients. The current clinical management of these two …

Current treatments for chronic neuropathic pain often fall short. A small‐molecular
compound ZL006 can suppress N‐Methyl‐d‐aspartate receptor (NMDAR)‐mediated …

Chronic pain, such as chronic neuropathic pain and chronic inflammatory pain, is often
difficult to manage and bring great trouble to patients. 5-HT plays a key role in the process of …

Pathological pain states arising from injuries to the nervous system are characterized by
sustained neuroinflammation and increased neuronal excitability at both peripheral and …

糖尿病周围神经病变是临床上常见的一种危害严重的慢性并发症, 其致残率极高,
不仅对患者的生命安全以及心理健康等造成巨大的伤害, 还会加重患者家庭乃至社会民生的负担 …

The opioid epidemic has transformed pain research, not only in the sense of urgency with
which analgesics are being developed, but also in the way in which hypotheses are being …