Plants evolve to synthesize various natural metabolites to protect themselves against
threats, such as insects, predators, microorganisms, and environmental conditions (such as …

In tumourigenesis, oncogenes or dysregulated tumour suppressor genes alter the canonical
translation machinery leading to a reprogramming of the translatome that, in turn, promotes …

Targeted cancer therapies using immunotoxins have achieved remarkable efficacy in
hematological malignancies. However, the clinical development of immunotoxins is also …

The development of safe and efficacious enzyme-based human therapies has increased
greatly in the last decades, thanks to remarkable advances in the understanding of the …

The continuing emergence of SARS-CoV-2 variants has highlighted the need to identify
additional points for viral inhibition. Ribosome inactivating proteins (RIPs), such as MAP30 …

Among all kinds of anticancer agents, small molecule drugs produce an unsatisfactory
therapeutic effect due to the lack of selectivity, notorious drug resistance and side effects …

Tian Hua Fen, a herbal powder extract that contains trichosanthin (TCS), was used as an
abortifacient in traditional Chinese medicine. In 1972, TCS was purified to alleviate the side …

Ribosome‐inactivating proteins, a family of highly cytotoxic proteins, interfere with protein
synthesis by depurinating a specific adenosine residue within the conserved α‐sarcin/ricin …

Ribosome-inactivating proteins (RIPs) are found in several edible plants and are well
characterized. Many studies highlight their use in cancer therapy, alone or as …

Monoclonal antibodies (mAbs) are included among the treatment options for advanced
colorectal cancer (CRC). However, while these mAbs effectively target cancer cells, they …