Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

In this review we will critically assess the hypothesis that the reinforcing effect of virtually all
drugs of abuse is primarily dependent on activation of the mesolimbic dopamine system …

Substance use disorder is characterized by repeated use of a substance, leading to
clinically significant distress, making it a serious public health concern. The …

Evidence that psychoactive substance use disorders, bulimia nervosa, pathological
gambling, and sexual addiction share an underlying biopsychological process is …

Recent studies have shown that the endocannabinoid system is involved in the common
neurobiological mechanism underlying drug addiction. This system participates in the …

Drug addiction presents as a chronic relapsing disorder characterized by persistent drug‐
seeking and drug‐taking behaviours. Given the significant detrimental effects of this disease …

2-Arachidonoylglycerol (2-AG) is a unique molecular species of monoacylglycerol isolated
in 1995 from rat brain and canine gut as an endogenous ligand for the cannabinoid …

Fueled by anatomical, electrophysiological, and pharmacological analyses of endogenous
brain reward systems, norepinephrine (NE) was identified as a key mediator of both natural …