Mitochondrial function and glucose metabolism play important roles in bidirectional
signaling between granulosa cells (GCs) and oocytes. However, the factors associated with …

Mammalian follicles are constituted of a complex structure composed of several layers of
granulosa cells surrounding the oocyte and of theca cells that reside beneath its basement …

The biggest cell in the human body, the oocyte, encloses almost the complete machinery to
start life. Despite all the research performed to date, defining oocyte quality is still a major …

Establishing an ideal human follicle culture system for oncofertility patients relies mainly on
animal models since donor tissue is scarce and often of suboptimal quality. The in vitro …

Female fertility decreases during aging. The development of effective therapeutic strategies
to address the age-related decline in oocyte quality and quantity and its accurate diagnosis …

Highlights What are the main findings? For the first time, ultrastructural alterations were
detected using transmission electron microscopy in human cumulus-oocyte complexes …

Copper hydroxide (Cu (OH) 2) nanopesticide formulas are becoming more frequently used
in agriculture; however, human exposure risks are not completely characterized. Here, the …

Pre-incubation of the cumulus-oocyte complex (COCs) may lead to better function of
cumulus cells (CCs) and higher oocyte quality by changing the transcriptomic profile of CCs …

Background: Aged women and premature ovarian insufficiency (POI) patients have residual
dormant primordial follicles that are hard to be activated through a physiological process …

Age-related changes in the mitochondrial status of human cumulus cells (hCCs) impact
oocyte quality; however, the relationship between hCC mitochondrial (dys) function and …