In cells of higher eukaryotes, repair of DNA double strand breaks (DSBs) utilizes different
forms of potentially error-prone non-homologous end joining (NHEJ): canonical DNA-PK …

DNA double-strand breaks are lesions that form during metabolism, DNA replication and
exposure to mutagens. When a double-strand break occurs one of a number of repair …

Modeling a biological process equips us with more comprehensive insight into the process
and a more advantageous experimental design. Non-homologous end joining (NHEJ) is a …

To obtain an overall picture of the repair of DNA single and double strand breaks in a
defined region of chromatin in vivo, we studied their repair in a∼ 170 kb circular …

Hyperthermia is widely used to treat patients with various types of cancers. However, the
molecular mechanisms involved in heat-induced cell killing are not yet fully understood …

In the search for ways of sensitizing tumor cells to chemotherapy or radiotherapy, the
inhibition of DNA repair has recently been proposed as a target of clinical interest. Ionizing …

Background Adeno‐associated virus type 2 (AAV) has the ability to target integration of its
DNA into a specific locus of the human genome. Site‐specific AAV integration is mediated …

Двойные разрывы ДНК, возникающие в результате метаболических клеточных
процессов и под воздействием внешних факторов, представляют серьезную опасность …

1. Introduction e genome is subject to various assaults by both exogenous environmental
factors (eg ionizing radiation, chemicals and reactive oxygen species) and endogenous …

Radiotherapy and most of the antineoplastic drugs induce directly or not the formation of
DNA damage among which double strand breaks (DSBs) represent the major toxic lesion …