Biochemical and genetic studies suggest that vertebrates remove double-strand breaks
(DSBs) from their genomes predominantly by two non-homologous end joining (NHEJ) …

To obtain an overall picture of the repair of DNA single and double strand breaks in a
defined region of chromatin in vivo, we studied their repair in a, 170 kb circular …

All living organisms face a constant barrage of DNA damage from anthropogenic and
naturally occurring external and endogenous sources, yet DNA provides the blueprint for all …

Eukaryotic organisms use two distinct pathways to repair DNA double-strand breaks (DSBs),
namely non-homologous end joining (NHEJ) and homologous recombination (HR). NHEJ …

Class switch recombination (CSR) in B lymphocytes is initiated by the introduction of
multiple DNA double-strand breaks (DSBs) into the switch (S) regions that flank …

Three DNA DSB repair pathways have been identified to date in human somatic cells: HR
(homologous recombination), C-NHEJ (classic non-homologous end joining) and A-NHEJ …

The foundation of proper embryonic development involves the precise control of embryonic
stem (ES) cell growth, proliferation, and subsequent differentiation. DNA damage …

• Abstract Functional interactions between components of the ligation complex of DNA
double strand break repair by Non-Homologous End-Joining DNA double-strand breaks …

抄録 ハイパーサーミアは様々なタイプのがん患者の治療に広く用いられている. しかしながら,
温熱誘導細胞死に関する分子機構については十分に解明されていない. タンパク質変性は温熱処理 …