Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …

Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …

Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Migraine and neuropathic pain (NP) are both painful, disabling, chronic conditions which
exhibit some symptom similarities and are thus considered to share a common etiology. The …

Chronic pain often occurs in the elderly, particularly in the patients with neurodegenerative
disorders such as Alzheimer's disease (AD). Although studies indicate that chronic pain …

Opioid drugs are potent modulators of many physiological and psychological processes.
When given acutely, they can elicit the signature responses of euphoria and analgesia that …

Neuropathic pain associated with nucleoside reverse transcriptase inhibitors (NRTIs),
therapeutic agents for human immunodeficiency virus (HIV), responds poorly to available …

Highlights•Neuroinflammation in limbic structures co-occurs in both chronic pain and opioid
dependence.•Major depressive disorder is associated with neuroinflammation.•Chronic pain …

Current deficiency in our understanding of acute-to-chronic pain transition remains a hurdle
for developing effective treatments against chronic pain. Whereas neurocentric mechanisms …